Imatinib-induced bone marrow necrosis detected on MRI examination and mimicking bone metastases

D. Vanel, S. Bonvalot, C. Le Pechoux, A. Cioffi, J. Domont, A. Le Cesne

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Imatinib has revolutionized the treatment and prognosis of patients with gastrointestinal stromal tumors (GIST). In contrast to liver and/or abdominal involvement, bone metastases are an uncommon event in GIST. We report here two patients with metastatic GIST who developed pelvic bone marrow focal lesions visible on MRI examinations, while Imatinib dramatically improved other tumor sites. A biopsy in one patient diagnosed bone marrow necrosis. The other patient had a favorable follow-up over several years, without bone metastases. Focal bone marrow abnormalities, detected on MRI examinations and mimicking bone metastases in patients who were otherwise responding, should be considered as probable bone marrow necrosis.

Original languageEnglish
Pages (from-to)895-898
Number of pages4
JournalSkeletal Radiology
Volume36
Issue number9
DOIs
Publication statusPublished - Sep 2007

Fingerprint

Osteonecrosis
Bone Marrow
Gastrointestinal Stromal Tumors
Neoplasm Metastasis
Bone and Bones
Pelvic Bones
Imatinib Mesylate
Biopsy
Liver
Neoplasms

Keywords

  • Bone marrow
  • GIST
  • Metastases
  • MRI
  • Necrosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Vanel, D., Bonvalot, S., Le Pechoux, C., Cioffi, A., Domont, J., & Le Cesne, A. (2007). Imatinib-induced bone marrow necrosis detected on MRI examination and mimicking bone metastases. Skeletal Radiology, 36(9), 895-898. https://doi.org/10.1007/s00256-007-0344-0

Imatinib-induced bone marrow necrosis detected on MRI examination and mimicking bone metastases. / Vanel, D.; Bonvalot, S.; Le Pechoux, C.; Cioffi, A.; Domont, J.; Le Cesne, A.

In: Skeletal Radiology, Vol. 36, No. 9, 09.2007, p. 895-898.

Research output: Contribution to journalArticle

Vanel, D, Bonvalot, S, Le Pechoux, C, Cioffi, A, Domont, J & Le Cesne, A 2007, 'Imatinib-induced bone marrow necrosis detected on MRI examination and mimicking bone metastases', Skeletal Radiology, vol. 36, no. 9, pp. 895-898. https://doi.org/10.1007/s00256-007-0344-0
Vanel, D. ; Bonvalot, S. ; Le Pechoux, C. ; Cioffi, A. ; Domont, J. ; Le Cesne, A. / Imatinib-induced bone marrow necrosis detected on MRI examination and mimicking bone metastases. In: Skeletal Radiology. 2007 ; Vol. 36, No. 9. pp. 895-898.
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