Imbalance between Pneumocystis carinii cysts and trophozoites in bronchoalveolar lavage fluid from patients with pneumocystosis receiving prophylaxis

Enrica Tamburrini, Paola Mencarini, Elena Visconti, A. De Luca, Maria Zolfo, Alessandra Siracusano, Elena Ortona, Rita Murri, A. Antinori

Research output: Contribution to journalArticlepeer-review

Abstract

Detection and quantification of different Pneumocystis carinii (PC) life cycle forms were performed by polymerase chain reaction (PCR) and by morphological stains on bronchoalveolar lavage fluids (BALF) from HIV- infected patients with P. carinii pneumonia (PCP). The number of PC trophozoites was higher in patients with PCP who were receiving prophylaxis than in those not receiving prophylaxis. Also the cyst: trophozoite ratio was lower in the first group. No difference was observed between patients receiving different prophylactic medications. The imbalance between PC forms in BALF from patients with PCP receiving anti-PC prophylaxis may hamper the sensitivity of cyst stains. Multiple stains or PCR examination should be performed on BALF from patients with clinically suspected PCP who are receiving prophylaxis.

Original languageEnglish
Pages (from-to)146-148
Number of pages3
JournalJournal of Medical Microbiology
Volume45
Issue number2
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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