Imbalance of circulating dendritic cell subsets in chronic obstructive pulmonary disease

Mario Galgani, Immacolata Fabozzi, Francesco Perna, Dario Bruzzese, Barbara Bellofiore, Cecilia Calabrese, Alessandro Vatrella, Domenico Galati, Giuseppe Matarese, Alessandro Sanduzzi, Marialuisa Bocchino

Research output: Contribution to journalArticlepeer-review

Abstract

Dendritic cells (DCs) play an unsettled role in chronic obstructive pulmonary disease (COPD) pathogenesis. Two main blood subsets, myeloid (m) and plasmacytoid (p) DCs, have been identified in humans. Phenotype and frequency of circulating DC subsets were assessed by multi-parametric flow cytometry in 28 COPD patients and 30 healthy controls (15 never smokers and 15 smokers). Proportion and absolute number of pDCs were significantly reduced in COPD patients in comparison with never smokers (p

Original languageEnglish
Pages (from-to)102-110
Number of pages9
JournalClinical Immunology
Volume137
Issue number1
DOIs
Publication statusPublished - Oct 2010

Keywords

  • Cigarette smoking
  • COPD
  • Dendritic cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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