TY - JOUR
T1 - Imbalance of circulating dendritic cell subsets in chronic obstructive pulmonary disease
AU - Galgani, Mario
AU - Fabozzi, Immacolata
AU - Perna, Francesco
AU - Bruzzese, Dario
AU - Bellofiore, Barbara
AU - Calabrese, Cecilia
AU - Vatrella, Alessandro
AU - Galati, Domenico
AU - Matarese, Giuseppe
AU - Sanduzzi, Alessandro
AU - Bocchino, Marialuisa
PY - 2010/10
Y1 - 2010/10
N2 - Dendritic cells (DCs) play an unsettled role in chronic obstructive pulmonary disease (COPD) pathogenesis. Two main blood subsets, myeloid (m) and plasmacytoid (p) DCs, have been identified in humans. Phenotype and frequency of circulating DC subsets were assessed by multi-parametric flow cytometry in 28 COPD patients and 30 healthy controls (15 never smokers and 15 smokers). Proportion and absolute number of pDCs were significantly reduced in COPD patients in comparison with never smokers (p
AB - Dendritic cells (DCs) play an unsettled role in chronic obstructive pulmonary disease (COPD) pathogenesis. Two main blood subsets, myeloid (m) and plasmacytoid (p) DCs, have been identified in humans. Phenotype and frequency of circulating DC subsets were assessed by multi-parametric flow cytometry in 28 COPD patients and 30 healthy controls (15 never smokers and 15 smokers). Proportion and absolute number of pDCs were significantly reduced in COPD patients in comparison with never smokers (p
KW - Cigarette smoking
KW - COPD
KW - Dendritic cells
UR - http://www.scopus.com/inward/record.url?scp=77956618830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956618830&partnerID=8YFLogxK
U2 - 10.1016/j.clim.2010.06.010
DO - 10.1016/j.clim.2010.06.010
M3 - Article
C2 - 20634141
AN - SCOPUS:77956618830
VL - 137
SP - 102
EP - 110
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 1
ER -