Imbalances in T cell subpopulations associated with immunodeficiency and autoimmune syndromes

L. Moretta, M. C. Mingari, S. R. Webb, E. R. Pearl, P. M. Lydyard, C. E. Grossi, A. R. Lawton, M. D. Cooper

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Abstract

Abnormal proportions of the distinct T cell subpopulations binding the Fc portion of IgM (T.(M)) cells and those bearing receptors for the Fc portion of IgG (T.(G)) cells, were observed in blood samples from patients who had congenital or acquired abnormalities of the thymus, severe combined immunodeficiency, or an unexplained primary deficiency in cell-mediated immunity; most had too few circulating T.(M) cells and often an overabundance of T.(G) cells. In an in vitro evaluation of lymphocytes from one of three thymoma patients with an elevated T.(G) subpopulation, removal of T.(G) cells abrogated the suppression of T.(M) cell help of B cell differentiation induced by pokeweed mitogen. A spectrum of patients with sex-linked infantile agammaglobulinemia, variable hypogammaglobulinemia, and selective IgA deficiency, and a few patients with autoimmune syndromes infrequently had distorted representation of these T cell subpopulations in the circulation. This suggests that B cell dysfunction in many of these patients is not merely due to numerical excesses or insufficiencies of helper or suppressor T cells.

Original languageEnglish
Pages (from-to)696-700
Number of pages5
JournalEuropean Journal of Immunology
Volume7
Issue number10
Publication statusPublished - 1977

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Gastrin-Secreting Cells
T-Lymphocytes
Agammaglobulinemia
B-Lymphocytes
IgA Deficiency
Severe Combined Immunodeficiency
Pokeweed Mitogens
Thymoma
Fc Receptors
Cellular Immunity
Thymus Gland
Immunoglobulin M
Cell Differentiation
Immunoglobulin G
Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Moretta, L., Mingari, M. C., Webb, S. R., Pearl, E. R., Lydyard, P. M., Grossi, C. E., ... Cooper, M. D. (1977). Imbalances in T cell subpopulations associated with immunodeficiency and autoimmune syndromes. European Journal of Immunology, 7(10), 696-700.

Imbalances in T cell subpopulations associated with immunodeficiency and autoimmune syndromes. / Moretta, L.; Mingari, M. C.; Webb, S. R.; Pearl, E. R.; Lydyard, P. M.; Grossi, C. E.; Lawton, A. R.; Cooper, M. D.

In: European Journal of Immunology, Vol. 7, No. 10, 1977, p. 696-700.

Research output: Contribution to journalArticle

Moretta, L, Mingari, MC, Webb, SR, Pearl, ER, Lydyard, PM, Grossi, CE, Lawton, AR & Cooper, MD 1977, 'Imbalances in T cell subpopulations associated with immunodeficiency and autoimmune syndromes', European Journal of Immunology, vol. 7, no. 10, pp. 696-700.
Moretta, L. ; Mingari, M. C. ; Webb, S. R. ; Pearl, E. R. ; Lydyard, P. M. ; Grossi, C. E. ; Lawton, A. R. ; Cooper, M. D. / Imbalances in T cell subpopulations associated with immunodeficiency and autoimmune syndromes. In: European Journal of Immunology. 1977 ; Vol. 7, No. 10. pp. 696-700.
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AU - Lawton, A. R.

AU - Cooper, M. D.

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