Imbalances of T cell subpopulations in patients with atopic diseases and effect of specific immunotherapy

G. W. Canonica, M. C. Mingari, G. Melioli, M. Colombatti, L. Moretta

Research output: Contribution to journalArticle

Abstract

Reduced numbers of T cells with Fc receptors for IgG [T(G) cells] are present in blood samples of patients with respiratory allergic disease, mainly those with severe symptoms. T(G) cells have been previously shown to be suppressor in the pokeweed mitogen- (PWM) dependent B cell differentiation. T cells with Fc receptor for IgM, which help immunoglobulin production, are in a normal range. After specific hyposensitization, resulting in a sharp improvement of clinical symptoms, T(G) cell subset reached normal values.

Original languageEnglish
Pages (from-to)2669-2672
Number of pages4
JournalJournal of Immunology
Volume123
Issue number6
Publication statusPublished - 1979

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ASJC Scopus subject areas

  • Immunology

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