Imidazole analogues of fluoxetine, a novel class of anti-Candida agents

Romano Silvestri, Marino Artico, Giuseppe La Regina, Alessandra Di Pasquali, Gabriella De Martino, Felicia Diodata D'Auria, Lucia Nencioni, Anna Teresa Palamara

Research output: Contribution to journalArticle

Abstract

Imidazole analogues of fluoxetine have been obtained by replacing the methylamino terminus of aminopropane chain with the imidazole ring. The newly designed imidazoles showed potent anti-Candida activity, superior to those of miconazole and other antifungal agents of clinical interest. 1-(4-Chlorophenyl)-l-(2,4-dichlorophenoxy)-3-(1H-imidazol-1-yl)propane (16), the most active among test imidazoles, Was about 2-fold more active and as much less cytotoxic than miconazole. High increase of activity was observed with methyl, nitro, fluorine, and chlorine (Cl > F > CH3 > NO2 > CF3).

Original languageEnglish
Pages (from-to)3924-3926
Number of pages3
JournalJournal of Medicinal Chemistry
Volume47
Issue number16
DOIs
Publication statusPublished - Jul 29 2004

ASJC Scopus subject areas

  • Organic Chemistry

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    Silvestri, R., Artico, M., La Regina, G., Di Pasquali, A., De Martino, G., D'Auria, F. D., Nencioni, L., & Palamara, A. T. (2004). Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. Journal of Medicinal Chemistry, 47(16), 3924-3926. https://doi.org/10.1021/jm049856v