Immediate and long-term clinical outcome after spinal cord stimulation for refractory stable angina pectoris

Francesco Di Pede, Gaetano Antonio Lanza, Guerrino Zuin, Ottavio Alfieri, Massimo Rapati, Massimo Romanò, Antonio Circo, Paola Cardano, Fulvio Bellocci, Massimo Santini, Attilio Maseri

Research output: Contribution to journalArticle


The treatment of patients with angina pectoris refractory to medical therapy and unsuitable for revascularization procedures has yet not been well standardized. Previous retrospective studies and small prospective studies have suggested beneficial effects of spinal cord stimulation (SCS) in these patients. We created a Prospective Italian Registry of SCS to evaluate the short- and long-term clinical outcome of patients who underwent SCS device implantation because of severe refractory angina pectoris. Overall, 104 patients were enrolled in the registry (70 men, aged 68 ± 17 years), most of whom (83%) had severe coronary artery disease. Average follow-up was 13.2 ± 8 months. Overall, 17 patients (16%) died, 8 (8%) due to cardiac death. Among clinical variables, only age was found to be significantly associated both with total mortality (p = 0.04) and cardiac mortality (p = 0.02) on Cox regression analysis. A significant improvement of anginal symptoms (≥50% reduction of weekly anginal episodes, compared with baseline) occurred in 73% of patients, and Canadian Cardiovacular Society angina class improved by ≥1 class in 80% and by ≥2 classes in 42% of patients, with a relevant reduction in the rate of hospital admission and days spent in the hospital because of angina (p

Original languageEnglish
Pages (from-to)951-955
Number of pages5
JournalThe American Journal of Cardiology
Issue number8
Publication statusPublished - Apr 15 2003


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this