Immediate effects of rhythmic auditory stimulation on gait kinematics in Parkinson's disease ON/OFF medication

Carmen Erra, Ilaria Mileti, M. Germanotta, Martina Petracca, Isabella Imbimbo, Alessandro De Biase, Stefano Rossi, D. Ricciardi, Alessandra Pacilli, Enrica Di Sipio, Eduardo Palermo, Anna Rita Bentivoglio, Luca Padua

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Gait impairment is a highly disabling symptom for Parkinson's disease (PD) patients. Rhythmic auditory stimulation (RAS), has shown to improve spatio-temporal gait parameters in PD, but only a few studies have focused on their effects on gait kinematics, and the ideal stimulation frequency has still not been identified. Methods: We enrolled 30 PD patients and 18 controls. Patients were evaluated under two conditions (with (ON), and without (OFF) medications) with three different RAS frequencies (90%, 100%, and 110% of the patient's preferred walking cadence). Spatial-temporal parameters, joint angles and gait phases distribution were evaluated. A novel global index (GPQI) was used to quantify the difference in gait phase distribution. Results: Along with benefits in spatial-temporal parameters, GPQI improved significantly with RAS at a frequency of 110% for both ON and OFF medication conditions. In the most severe patients, the same result was observed also with RAS at 100%. Conclusions: RAS administration, at a frequency of 110% of the preferred walking frequency, can be beneficial in improving the gait pattern in PD patients. Significance: When rhythmic auditory stimulation is provided to patients with PD, the selection of an adequate frequency of stimulation can optimize their effects on gait pattern.

Original languageEnglish
Pages (from-to)1789-1797
Number of pages9
JournalClinical Neurophysiology
Volume130
Issue number10
DOIs
Publication statusPublished - Oct 1 2019

Keywords

  • Gait analysis
  • Kinematic
  • Parkinson disease
  • Personalized medicine
  • Rehabilitation
  • Rhythmic auditory stimulation

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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