Immobilized amyloid Aβ peptides support platelet adhesion and activation

Ilaria Canobbio, Silvia Catricalà, Laura G. Di Pasqua, Gianni Guidetti, Alessandra Consonni, Daria Manganaro, Mauro Torti

Research output: Contribution to journalArticle

Abstract

Accumulation of amyloidogenic Aβ peptides in the brain contributes to the onset of Alzheimer disease. Aβ peptide deposits are also present in blood vessel walls, mainly deriving from circulating platelets. However, their effect on platelet function is unclear. We demonstrate that immobilized Aβ peptides induce platelet adhesion and spreading through metalloproteinase- sensitive surface receptors. Aβ peptides also fasten platelet spreading on collagen, and support the time- and ADP-dependent activation of adherent platelets, leading to stimulation of several signalling proteins. Our results indicate a potential role for peripheral Aβ peptides in promoting platelet adhesion and activation in the initiation of thrombus formation.

Original languageEnglish
Pages (from-to)2606-2611
Number of pages6
JournalFEBS Letters
Volume587
Issue number16
DOIs
Publication statusPublished - Aug 19 2013

Keywords

  • Aβ peptide
  • Adhesion
  • Amyloid
  • Cerebrovascular inflammation
  • Human platelet

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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