IMMSIM, a flexible model for in machina experiments on immune system responses

R. Puzone, B. Kohler, P. Seiden, F. Celada

Research output: Contribution to journalArticle

Abstract

This paper describes the basic structure and the developments of IMMSIM, a modified cellular automaton to simulate chance encounters and discrete effects of cell-cell and cell-molecule interactions in the lymphoid system. Thanks to its flexibility, this model has proven a useful tool in theoretical immunology, experimental research and educational applications. Of the various versions available, we show here the most advanced one (IMMSIM3), that incorporates both humoral and cellular responses. We describe the results obtained by simulating the responses to viral infection, the impact of viral behavior on the quality of response needed to reach a cure, the cooperation/competition relation between cellular and humoral branches and the effect of vaccination.

Original languageEnglish
Pages (from-to)961-972
Number of pages12
JournalFuture Generation Computer Systems
Volume18
Issue number7
DOIs
Publication statusPublished - Jul 2002

Fingerprint

Immunology
Immune system
Cellular automata
Molecules
Experiments

Keywords

  • Cellular automata
  • Computer simulation
  • Immune system

ASJC Scopus subject areas

  • Computer Science Applications
  • Hardware and Architecture
  • Control and Systems Engineering

Cite this

IMMSIM, a flexible model for in machina experiments on immune system responses. / Puzone, R.; Kohler, B.; Seiden, P.; Celada, F.

In: Future Generation Computer Systems, Vol. 18, No. 7, 07.2002, p. 961-972.

Research output: Contribution to journalArticle

Puzone, R. ; Kohler, B. ; Seiden, P. ; Celada, F. / IMMSIM, a flexible model for in machina experiments on immune system responses. In: Future Generation Computer Systems. 2002 ; Vol. 18, No. 7. pp. 961-972.
@article{31b6eeed62ca43e49931d2434a432df7,
title = "IMMSIM, a flexible model for in machina experiments on immune system responses",
abstract = "This paper describes the basic structure and the developments of IMMSIM, a modified cellular automaton to simulate chance encounters and discrete effects of cell-cell and cell-molecule interactions in the lymphoid system. Thanks to its flexibility, this model has proven a useful tool in theoretical immunology, experimental research and educational applications. Of the various versions available, we show here the most advanced one (IMMSIM3), that incorporates both humoral and cellular responses. We describe the results obtained by simulating the responses to viral infection, the impact of viral behavior on the quality of response needed to reach a cure, the cooperation/competition relation between cellular and humoral branches and the effect of vaccination.",
keywords = "Cellular automata, Computer simulation, Immune system",
author = "R. Puzone and B. Kohler and P. Seiden and F. Celada",
year = "2002",
month = "7",
doi = "10.1016/S0167-739X(02)00075-4",
language = "English",
volume = "18",
pages = "961--972",
journal = "Future Generation Computer Systems",
issn = "0167-739X",
publisher = "Elsevier",
number = "7",

}

TY - JOUR

T1 - IMMSIM, a flexible model for in machina experiments on immune system responses

AU - Puzone, R.

AU - Kohler, B.

AU - Seiden, P.

AU - Celada, F.

PY - 2002/7

Y1 - 2002/7

N2 - This paper describes the basic structure and the developments of IMMSIM, a modified cellular automaton to simulate chance encounters and discrete effects of cell-cell and cell-molecule interactions in the lymphoid system. Thanks to its flexibility, this model has proven a useful tool in theoretical immunology, experimental research and educational applications. Of the various versions available, we show here the most advanced one (IMMSIM3), that incorporates both humoral and cellular responses. We describe the results obtained by simulating the responses to viral infection, the impact of viral behavior on the quality of response needed to reach a cure, the cooperation/competition relation between cellular and humoral branches and the effect of vaccination.

AB - This paper describes the basic structure and the developments of IMMSIM, a modified cellular automaton to simulate chance encounters and discrete effects of cell-cell and cell-molecule interactions in the lymphoid system. Thanks to its flexibility, this model has proven a useful tool in theoretical immunology, experimental research and educational applications. Of the various versions available, we show here the most advanced one (IMMSIM3), that incorporates both humoral and cellular responses. We describe the results obtained by simulating the responses to viral infection, the impact of viral behavior on the quality of response needed to reach a cure, the cooperation/competition relation between cellular and humoral branches and the effect of vaccination.

KW - Cellular automata

KW - Computer simulation

KW - Immune system

UR - http://www.scopus.com/inward/record.url?scp=0036640183&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036640183&partnerID=8YFLogxK

U2 - 10.1016/S0167-739X(02)00075-4

DO - 10.1016/S0167-739X(02)00075-4

M3 - Article

AN - SCOPUS:0036640183

VL - 18

SP - 961

EP - 972

JO - Future Generation Computer Systems

JF - Future Generation Computer Systems

SN - 0167-739X

IS - 7

ER -