Immune abnormalities and endotoxemia in patients with ulcerative colitis and in their first degree relatives: Attempts at neutralizing endotoxin-mediated effects

L. Amati, L. Caradonna, G. Leandro, T. Magrone, M. Minenna, G. Faleo, N. M. Pellegrino, E. Jirillo, D. Caccavo

Research output: Contribution to journalArticle

Abstract

Proinflammatory cytokines released from in monocytes/macrophages, in particular tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, and IL-8 seem to play an important role in Inflammatory Bowel Disease (ulcerative colitis and Crohn's disease). Endotoxins or lipopolysaccharides, derived from the outer membrane of Gram-negative bacteria interact with CD14 on surface membrane of macrophages, thus triggering a signal cascade, which leads to the production and release of proinflammatory cytokines, particularly TNF-α Therefore, in IBD, lipopolysaccharides could play a pathogenic role. In this respect, plasma endotoxins have been demonstrated in a not negligible percentage of patients with ulcerative colitis and in their unaffected relatives. The presence of circulating endotoxins could be due, at least in part, to the impaired natural immunity in either patients with ulcerative colitis or in their first degree unaffected relatives. Lactoferrin is an iron-binding glycoprotein, which binds to the lipid A region of lipopolysaccharide with a high affinity and this interaction prevents the binding of lipopolysaccharide to CD14, thus inhibiting the release of proinflammatory cytokines. Therefore, based on the possible pathogenic role exerted by endotoxins in ulcerative colitis, lactoferrin may deserve attention as a possible therapeutical agent in experimental models of Inflammatory Bowel Disease.

Original languageEnglish
Pages (from-to)1937-1945
Number of pages9
JournalCurrent Pharmaceutical Design
Volume9
Issue number24
DOIs
Publication statusPublished - 2003

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Endotoxemia
Ulcerative Colitis
Endotoxins
Lipopolysaccharides
Lactoferrin
Cytokines
Inflammatory Bowel Diseases
Tumor Necrosis Factor-alpha
Macrophages
Lipid A
Membranes
Gram-Negative Bacteria
Interleukin-8
Interleukin-1
Innate Immunity
Crohn Disease
Monocytes
Interleukin-6
Glycoproteins
Theoretical Models

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Immune abnormalities and endotoxemia in patients with ulcerative colitis and in their first degree relatives : Attempts at neutralizing endotoxin-mediated effects. / Amati, L.; Caradonna, L.; Leandro, G.; Magrone, T.; Minenna, M.; Faleo, G.; Pellegrino, N. M.; Jirillo, E.; Caccavo, D.

In: Current Pharmaceutical Design, Vol. 9, No. 24, 2003, p. 1937-1945.

Research output: Contribution to journalArticle

Amati, L. ; Caradonna, L. ; Leandro, G. ; Magrone, T. ; Minenna, M. ; Faleo, G. ; Pellegrino, N. M. ; Jirillo, E. ; Caccavo, D. / Immune abnormalities and endotoxemia in patients with ulcerative colitis and in their first degree relatives : Attempts at neutralizing endotoxin-mediated effects. In: Current Pharmaceutical Design. 2003 ; Vol. 9, No. 24. pp. 1937-1945.
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