TY - JOUR
T1 - Immune activation in myasthenia gravis
T2 - Soluble interleukin-2 receptor, interferon-γ and tumor necrosis factor-α levels in patients' serum
AU - Confalonieri, Paolo
AU - Antozzi, Carlo
AU - Cornelio, Ferdinando
AU - Simoncini, Ornella
AU - Mantegazza, Renato
PY - 1993
Y1 - 1993
N2 - Soluble interleukin-2 receptor (sIL-2R), interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were evaluated in serum from patients affected by myasthenia gravis (MG). sIL-2R titers were significantly increased in generalized and bulbar MG patients while ocular cases were not different from controls. Patients showing a recent clinical worsening had significantly higher sIL-2R titers when compared to the whole MG population. sIL-2R levels did not correlate with the corresponding anti-acetylcholine receptor antibody titer (Anti-AChR Ab). IFN-γ was not detected in serum of both MG patients and healthy subjects while TNF-α levels were not statistically different from controls. The finding of increased sIL-2R levels supports the hypothesis of circulating activated autoreactive T cells in myasthenic patients.
AB - Soluble interleukin-2 receptor (sIL-2R), interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were evaluated in serum from patients affected by myasthenia gravis (MG). sIL-2R titers were significantly increased in generalized and bulbar MG patients while ocular cases were not different from controls. Patients showing a recent clinical worsening had significantly higher sIL-2R titers when compared to the whole MG population. sIL-2R levels did not correlate with the corresponding anti-acetylcholine receptor antibody titer (Anti-AChR Ab). IFN-γ was not detected in serum of both MG patients and healthy subjects while TNF-α levels were not statistically different from controls. The finding of increased sIL-2R levels supports the hypothesis of circulating activated autoreactive T cells in myasthenic patients.
KW - Autoimmunity
KW - Interferon-γ
KW - Myasthenia gravis
KW - Soluble interleukin-2 receptor
KW - Tumor necrosis factor-α
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U2 - 10.1016/0165-5728(93)90055-4
DO - 10.1016/0165-5728(93)90055-4
M3 - Article
C2 - 8227305
AN - SCOPUS:0027372469
VL - 48
SP - 33
EP - 36
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1
ER -