Immune activation in myasthenia gravis: Soluble interleukin-2 receptor, interferon-γ and tumor necrosis factor-α levels in patients' serum

Paolo Confalonieri, Carlo Antozzi, Ferdinando Cornelio, Ornella Simoncini, Renato Mantegazza

Research output: Contribution to journalArticle

Abstract

Soluble interleukin-2 receptor (sIL-2R), interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were evaluated in serum from patients affected by myasthenia gravis (MG). sIL-2R titers were significantly increased in generalized and bulbar MG patients while ocular cases were not different from controls. Patients showing a recent clinical worsening had significantly higher sIL-2R titers when compared to the whole MG population. sIL-2R levels did not correlate with the corresponding anti-acetylcholine receptor antibody titer (Anti-AChR Ab). IFN-γ was not detected in serum of both MG patients and healthy subjects while TNF-α levels were not statistically different from controls. The finding of increased sIL-2R levels supports the hypothesis of circulating activated autoreactive T cells in myasthenic patients.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalJournal of Neuroimmunology
Volume48
Issue number1
DOIs
Publication statusPublished - 1993

Fingerprint

Interleukin-2 Receptors
Myasthenia Gravis
Interferons
Tumor Necrosis Factor-alpha
Serum
Muscle Weakness
Cholinergic Receptors
Healthy Volunteers
T-Lymphocytes
Antibodies
Population

Keywords

  • Autoimmunity
  • Interferon-γ
  • Myasthenia gravis
  • Soluble interleukin-2 receptor
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

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title = "Immune activation in myasthenia gravis: Soluble interleukin-2 receptor, interferon-γ and tumor necrosis factor-α levels in patients' serum",
abstract = "Soluble interleukin-2 receptor (sIL-2R), interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were evaluated in serum from patients affected by myasthenia gravis (MG). sIL-2R titers were significantly increased in generalized and bulbar MG patients while ocular cases were not different from controls. Patients showing a recent clinical worsening had significantly higher sIL-2R titers when compared to the whole MG population. sIL-2R levels did not correlate with the corresponding anti-acetylcholine receptor antibody titer (Anti-AChR Ab). IFN-γ was not detected in serum of both MG patients and healthy subjects while TNF-α levels were not statistically different from controls. The finding of increased sIL-2R levels supports the hypothesis of circulating activated autoreactive T cells in myasthenic patients.",
keywords = "Autoimmunity, Interferon-γ, Myasthenia gravis, Soluble interleukin-2 receptor, Tumor necrosis factor-α",
author = "Paolo Confalonieri and Carlo Antozzi and Ferdinando Cornelio and Ornella Simoncini and Renato Mantegazza",
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AU - Antozzi, Carlo

AU - Cornelio, Ferdinando

AU - Simoncini, Ornella

AU - Mantegazza, Renato

PY - 1993

Y1 - 1993

N2 - Soluble interleukin-2 receptor (sIL-2R), interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were evaluated in serum from patients affected by myasthenia gravis (MG). sIL-2R titers were significantly increased in generalized and bulbar MG patients while ocular cases were not different from controls. Patients showing a recent clinical worsening had significantly higher sIL-2R titers when compared to the whole MG population. sIL-2R levels did not correlate with the corresponding anti-acetylcholine receptor antibody titer (Anti-AChR Ab). IFN-γ was not detected in serum of both MG patients and healthy subjects while TNF-α levels were not statistically different from controls. The finding of increased sIL-2R levels supports the hypothesis of circulating activated autoreactive T cells in myasthenic patients.

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