Abstract
Soluble interleukin-2 receptor (sIL-2R), interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were evaluated in serum from patients affected by myasthenia gravis (MG). sIL-2R titers were significantly increased in generalized and bulbar MG patients while ocular cases were not different from controls. Patients showing a recent clinical worsening had significantly higher sIL-2R titers when compared to the whole MG population. sIL-2R levels did not correlate with the corresponding anti-acetylcholine receptor antibody titer (Anti-AChR Ab). IFN-γ was not detected in serum of both MG patients and healthy subjects while TNF-α levels were not statistically different from controls. The finding of increased sIL-2R levels supports the hypothesis of circulating activated autoreactive T cells in myasthenic patients.
| Original language | English |
|---|---|
| Pages (from-to) | 33-36 |
| Number of pages | 4 |
| Journal | Journal of Neuroimmunology |
| Volume | 48 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1993 |
Fingerprint
Keywords
- Autoimmunity
- Interferon-γ
- Myasthenia gravis
- Soluble interleukin-2 receptor
- Tumor necrosis factor-α
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Clinical Neurology
- Neurology
Cite this
Immune activation in myasthenia gravis : Soluble interleukin-2 receptor, interferon-γ and tumor necrosis factor-α levels in patients' serum. / Confalonieri, Paolo; Antozzi, Carlo; Cornelio, Ferdinando; Simoncini, Ornella; Mantegazza, Renato.
In: Journal of Neuroimmunology, Vol. 48, No. 1, 1993, p. 33-36.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immune activation in myasthenia gravis
T2 - Soluble interleukin-2 receptor, interferon-γ and tumor necrosis factor-α levels in patients' serum
AU - Confalonieri, Paolo
AU - Antozzi, Carlo
AU - Cornelio, Ferdinando
AU - Simoncini, Ornella
AU - Mantegazza, Renato
PY - 1993
Y1 - 1993
N2 - Soluble interleukin-2 receptor (sIL-2R), interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were evaluated in serum from patients affected by myasthenia gravis (MG). sIL-2R titers were significantly increased in generalized and bulbar MG patients while ocular cases were not different from controls. Patients showing a recent clinical worsening had significantly higher sIL-2R titers when compared to the whole MG population. sIL-2R levels did not correlate with the corresponding anti-acetylcholine receptor antibody titer (Anti-AChR Ab). IFN-γ was not detected in serum of both MG patients and healthy subjects while TNF-α levels were not statistically different from controls. The finding of increased sIL-2R levels supports the hypothesis of circulating activated autoreactive T cells in myasthenic patients.
AB - Soluble interleukin-2 receptor (sIL-2R), interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were evaluated in serum from patients affected by myasthenia gravis (MG). sIL-2R titers were significantly increased in generalized and bulbar MG patients while ocular cases were not different from controls. Patients showing a recent clinical worsening had significantly higher sIL-2R titers when compared to the whole MG population. sIL-2R levels did not correlate with the corresponding anti-acetylcholine receptor antibody titer (Anti-AChR Ab). IFN-γ was not detected in serum of both MG patients and healthy subjects while TNF-α levels were not statistically different from controls. The finding of increased sIL-2R levels supports the hypothesis of circulating activated autoreactive T cells in myasthenic patients.
KW - Autoimmunity
KW - Interferon-γ
KW - Myasthenia gravis
KW - Soluble interleukin-2 receptor
KW - Tumor necrosis factor-α
UR - http://www.scopus.com/inward/record.url?scp=0027372469&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027372469&partnerID=8YFLogxK
U2 - 10.1016/0165-5728(93)90055-4
DO - 10.1016/0165-5728(93)90055-4
M3 - Article
C2 - 8227305
AN - SCOPUS:0027372469
VL - 48
SP - 33
EP - 36
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1
ER -