Circadian variations of some immunological and endocrine functions were studied after placebo and after single i.m. administration of thymostimulin in six healthy male individuals. Comparison of the results obtained indicates that thymostimulin does exert immune and endocrine effects in man, the most outstanding of which are depression of circadian cortisol values and enhancement of NK activity. The absolute number of peripheral lymphocytes and their responsiveness to mitogens were also positively affected, whereas other endocrine or immunological parameters were only slightly modified, if at all. No certain proof was found to establish if the endocrine and the immune effects observed were direct or mediated, independent or correlated. Moreover, some evidence from other authors suggests that different thymic extracts or peptides possess uneven activities, thus making further analyses necessary to better understand the present findings.
|Number of pages||6|
|Journal||International Journal of Immunotherapy|
|Publication status||Published - 1990|
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