Immune balance in the synovial fluid of rheumatoid arthritis patients: Effects of intra-articular injection of thymopentin

A. Afeltra, M. Galeazzi, P. Basso, A. Pietrucci, O. De Pita, G. M. Ferri, F. Porzio, L. Bonomo

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Abstract

T cell subsets in the synovial fluid (SF) and peripheral blood (PB) of RA patients and controls suffering from different forms of chronic synovitis have been investigated. The immunological evaluation showed a reduction of CD4 subsets in RA-SF compared to RA-PB (p <0.001), and an almost complete absence of the suppressor-inducer/naive T cells in RA-SF compared to RA-PB and SF from patients with other forms of chronic synovitis. The CD8 subpopulation showed an increased proportion of cytotoxic cells only in RA-SF. On the basis of these results, an intra-articular immunomodulating treatment with thymopentin has been performed: its effects were characterized by an increase of CD8+CD11b+ T cells in the CD8 subset parallel to the enhancement of the suppressor-inducer/naive T cells in the CD4 subset with a statistically significant correlation. The enhanced levels of soluble CD8 decreased after treatment in RA-SF, whereas the soluble IL-2R levels were not significantly modified. Clinical evaluation showed a significative amelioration in all considered parameters.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Volume5
Issue number2
Publication statusPublished - 1991

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ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

Cite this

Afeltra, A., Galeazzi, M., Basso, P., Pietrucci, A., De Pita, O., Ferri, G. M., Porzio, F., & Bonomo, L. (1991). Immune balance in the synovial fluid of rheumatoid arthritis patients: Effects of intra-articular injection of thymopentin. Journal of Biological Regulators and Homeostatic Agents, 5(2), 71-75.