Immune checkpoint inhibitor-related myositis: From biology to bedside

Antonio G. Solimando, Lucilla Crudele, Patrizia Leone, Antonella Argentiero, Matteo Guarascio, Nicola Silvestris, Angelo Vacca, Vito Racanelli

Research output: Contribution to journalReview articlepeer-review

Abstract

Immune checkpoint inhibitor (ICI)-related inflammatory diseases, including polymyositis (PM) and dermatomyositis (DM), in patients suffering from neoplastic disorders represent a medical challenge. The treatment of these conditions has taken on new urgency due to the successful and broad development of cancer-directed immunological-based therapeutic strategies. While primary and secondary PM/DM phenotypes have been pathophysiologically characterized, a rational, stepwise approach to the treatment of patients with ICI-related disease is lacking. In the absence of high-quality evidence to guide clinical judgment, the available data must be critically assessed. In this literature review, we examine partially neglected immunological and clinical findings to obtain insights into the biological profiles of ICI-related PM/DM and potential treatment options. We show that differential diagnosis is essential to stratifying patients according to prognosis and therapeutic impact. Finally, we provide a comprehensive assessment of druggable targets and suggest a stepwise patient-oriented approach for the treatment of ICI-related PM/DM.

Original languageEnglish
Article number3054
JournalInternational Journal of Molecular Sciences
Volume21
Issue number9
DOIs
Publication statusPublished - May 1 2020

Keywords

  • Autoimmunity
  • Cancer
  • Dermatomyositis
  • Immune checkpoint inhibitors
  • Immune-related adverse events
  • Myositis
  • Polymyositis

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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