Immune checkpoint inhibitors and response analysis: A tough challenge. A case report

Alessandra Bearz, Tiziana Perin, Luca Cancian, Eleonora Berto, Ivana Sartor, Umberto Tirelli

Research output: Contribution to journalArticle

Abstract

Background: Treatment of metastatic NSCLC patients with immune-checkpoint medicine is intriguing for the potential efficacy; however it may be difficult to evaluate the clinical response due to the lack of reliable immune-monitoring markers up to now and the possibility of radiological pseudo-progression. Case presentation: Herein we report the case of a patient ex-smoker with adenocarcinoma of the lung, stage IV for liver metastases, in progression after cisplatin-based chemotherapy and treated with antiPD-L1 (MPDL3802-Roche Genentech) e.v. every 3 weeks in a clinical trial. Treatment with antiPD-L1 was well tolerated and CT scan after 6 weeks of treatment showed stabilization of mediastinal lymph nodes, while progression of liver metastases; liver progression only was confirmed by further CT-scans. Patient was asymptomatic and it was unclear if we faced a pseudo-progression in the liver or a real progression. Data about his PDL1 expression were not available because the patient was in a clinical trial. Eventually a biopsy of the liver metastasis confirmed that there was a massive neoplastic invasion with tumor infiltrating lymphocytes

Original languageEnglish
Article number349
JournalBMC Research Notes
Volume9
Issue number1
DOIs
Publication statusPublished - Jul 18 2016

Keywords

  • Immune-checkpoint inhibitors
  • NSCLC
  • Radiologic response

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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