Immune Checkpoint Inhibitors: Anti-NKG2A Antibodies on Board

Research output: Contribution to journalShort survey

Abstract

Antibodies directed towards checkpoint inhibitors have unveiled extraordinary potential in cancer therapy. An article by the Vivier group (Cell 2018;175:1731–1743) shows that blocking the HLA-E-specific NKG2A inhibitory receptor, expressed by NK and inducible in T cells, results in benefits against poor prognosis tumors. Moreover, NKG2A and PD-1/PD-L1 mAb combinations unleash tumor-specific T cell proliferation and memory.

Original languageEnglish
Pages (from-to)83-85
Number of pages3
JournalTrends in Immunology
Volume40
Issue number2
DOIs
Publication statusPublished - Feb 1 2019

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Anti-Idiotypic Antibodies
NK Cell Lectin-Like Receptor Subfamily C
T-Lymphocytes
Neoplasms
Cell Proliferation
Antibodies
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Immune Checkpoint Inhibitors : Anti-NKG2A Antibodies on Board. / Mingari, Maria Cristina; Pietra, Gabriella; Moretta, Lorenzo.

In: Trends in Immunology, Vol. 40, No. 2, 01.02.2019, p. 83-85.

Research output: Contribution to journalShort survey

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