Immune Checkpoint Inhibitors in Epithelial Ovarian Cancer: An Overview on Efficacy and Future Perspectives

Fulvio Borella, Eleonora Ghisoni, Gaia Giannone, Stefano Cosma, Chiara Benedetto, Giorgio Valabrega, Dionyssios Katsaros

Research output: Contribution to journalReview articlepeer-review

Abstract

Epithelial ovarian cancer (EOC) is the leading cause of death among gynecological cancers. Despite improvements in medical treatments, the prognosis for EOC remains poor, and there is an urgent need for new therapeutic strategies. Immune checkpoint inhibitors (CPIs) have dramatically improved survival of several cancers and are under evaluation in OC. Unfortunately, CPIs have shown globally unsatisfactory results. The aim of this manuscript is to critically review the results from early-phase trials with CPIs in terms of safety and activity, discuss the possible reasons for disappointing results and the new therapeutic approaches to improve patient outcomes.

Original languageEnglish
JournalDiagn.
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 7 2020

Fingerprint Dive into the research topics of 'Immune Checkpoint Inhibitors in Epithelial Ovarian Cancer: An Overview on Efficacy and Future Perspectives'. Together they form a unique fingerprint.

Cite this