Abstract
Background: Acute hemorrhagic edema of young children is a benign skin-limited vasculitis mainly affecting children 2 to 24 months of age, which is often considered the infantile variant of immunoglobulin A vasculitis (Henoch-Schönlein purpura). In most cases, the diagnosis is made on a clinical basis without a skin biopsy. Methods: A systematic review of the literature was performed to examine the reported prevalence of vascular immune deposits in skin biopsies of patients with acute hemorrhagic edema of young children. Results: Testing for vascular immune deposits was performed in 75 cases (64 boys and 11 girls aged from 3.5 to 72, median 11 months) published between 1970 and 2018. Vessel wall deposition of complement C3 was seen in 40 cases. Immunoglobulin M (N = 24), immunoglobulin A (N = 21), immunoglobulin G (N = 13), and immunoglobulin E (N = 3) were less frequently detected. Gender, age, clinical features, and disease duration were not statistically different in cases with and without vessel wall deposition of immunoglobulin A. Conclusion: Immune deposits in skin vessels, most frequently complement C3, are common in subjects with acute hemorrhagic edema of young children, providing furhter evidence that acute hemorrhagic edema, immunoglobulin A vasculitis, and pauci-immune vasculitides are different entities.
| Original language | English |
|---|---|
| Journal | Pediatric Dermatology |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2019 |
Fingerprint
Keywords
- Finkelstein-Seidlmayer syndrome
- Henoch-Schönlein syndrome
- Immunoglobulin A
- immunohistochemistry
- small-vessel leukocytoclastic vasculitis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Dermatology
Cite this
Immune deposits in skin vessels of patients with acute hemorrhagic edema of young children : A systematic literature review. / Pellanda, Giorgia; Lava, Sebastiano A.G.; Milani, Gregorio P.; Bianchetti, Mario G.; Ferrarini, Alessandra; Vanoni, Federica.
In: Pediatric Dermatology, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immune deposits in skin vessels of patients with acute hemorrhagic edema of young children
T2 - A systematic literature review
AU - Pellanda, Giorgia
AU - Lava, Sebastiano A.G.
AU - Milani, Gregorio P.
AU - Bianchetti, Mario G.
AU - Ferrarini, Alessandra
AU - Vanoni, Federica
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Acute hemorrhagic edema of young children is a benign skin-limited vasculitis mainly affecting children 2 to 24 months of age, which is often considered the infantile variant of immunoglobulin A vasculitis (Henoch-Schönlein purpura). In most cases, the diagnosis is made on a clinical basis without a skin biopsy. Methods: A systematic review of the literature was performed to examine the reported prevalence of vascular immune deposits in skin biopsies of patients with acute hemorrhagic edema of young children. Results: Testing for vascular immune deposits was performed in 75 cases (64 boys and 11 girls aged from 3.5 to 72, median 11 months) published between 1970 and 2018. Vessel wall deposition of complement C3 was seen in 40 cases. Immunoglobulin M (N = 24), immunoglobulin A (N = 21), immunoglobulin G (N = 13), and immunoglobulin E (N = 3) were less frequently detected. Gender, age, clinical features, and disease duration were not statistically different in cases with and without vessel wall deposition of immunoglobulin A. Conclusion: Immune deposits in skin vessels, most frequently complement C3, are common in subjects with acute hemorrhagic edema of young children, providing furhter evidence that acute hemorrhagic edema, immunoglobulin A vasculitis, and pauci-immune vasculitides are different entities.
AB - Background: Acute hemorrhagic edema of young children is a benign skin-limited vasculitis mainly affecting children 2 to 24 months of age, which is often considered the infantile variant of immunoglobulin A vasculitis (Henoch-Schönlein purpura). In most cases, the diagnosis is made on a clinical basis without a skin biopsy. Methods: A systematic review of the literature was performed to examine the reported prevalence of vascular immune deposits in skin biopsies of patients with acute hemorrhagic edema of young children. Results: Testing for vascular immune deposits was performed in 75 cases (64 boys and 11 girls aged from 3.5 to 72, median 11 months) published between 1970 and 2018. Vessel wall deposition of complement C3 was seen in 40 cases. Immunoglobulin M (N = 24), immunoglobulin A (N = 21), immunoglobulin G (N = 13), and immunoglobulin E (N = 3) were less frequently detected. Gender, age, clinical features, and disease duration were not statistically different in cases with and without vessel wall deposition of immunoglobulin A. Conclusion: Immune deposits in skin vessels, most frequently complement C3, are common in subjects with acute hemorrhagic edema of young children, providing furhter evidence that acute hemorrhagic edema, immunoglobulin A vasculitis, and pauci-immune vasculitides are different entities.
KW - Finkelstein-Seidlmayer syndrome
KW - Henoch-Schönlein syndrome
KW - Immunoglobulin A
KW - immunohistochemistry
KW - small-vessel leukocytoclastic vasculitis
UR - http://www.scopus.com/inward/record.url?scp=85075467862&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075467862&partnerID=8YFLogxK
U2 - 10.1111/pde.14041
DO - 10.1111/pde.14041
M3 - Article
C2 - 31755135
AN - SCOPUS:85075467862
JO - Pediatric Dermatology
JF - Pediatric Dermatology
SN - 0736-8046
ER -