Immune dysfunction in the elderly: Effect of thymic hormone administration on several in vivo and in vitro immune function parameters

Umberto Fagiolo, A. Amadori, F. Borghesan, R. Zamarchi, M. L. Veronese, G. De Silvestro, E. Passarella, G. Crepaldi

Research output: Contribution to journalArticle

Abstract

The effects of short- term thymic hormone administration on age- associated immune function were evaluated. Two groups of individuals > 65 years of age were treated for 30 days with thymic extracts (TP1) or placebo; before and after this treatment a panel of in vitro and in vivo parameters was determined according to a very rigorous experimental protocol. In most individuals, TP1 treatment was associated with an improvement in cutaneous delayed- type response to PPD. Moreover, an increase in a circulating T cell subpopulation bearing the CD45R surface antigen (“virgin” T cells), and in NK cell cytotoxic activity was also observed in some subjects. Finally, lymphocyte responsiveness to PHA tended to increase, while no effect on lymphocyte ability to produce IL- 2 following mitogen stimulation was observed. These findings suggest that TP1 treatment may influence age- related alterations in immune function parameters in some subjects. (Again 2: 347–355, 1990)

Original languageEnglish
Pages (from-to)347-355
Number of pages9
JournalAging clinical and experimental research
Volume2
Issue number4
DOIs
Publication statusPublished - 1990

Keywords

  • age-associated immune defect
  • Aging
  • immunotherapy
  • thymic hormones
  • TP1

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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