Immune effects of polychlorinated biphenyls, smoking and alcohol

Maria Nicolà D'Errico, G. De Tullio, M. Di Gioacchino, P. Lovreglio, A. Basso, I. Drago, R. Serra, P. Apostoli, A. Vacca, L. Soleo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Polychlorinated biphenyls (PCB) have been shown to exert some immune effects. Here we analysed their effects also on immune parameters not previously studied such as TCR α-β, TCR γ-δ and regulatory T cells (Treg), taking into account the specific and cumulative interference of smoking and alcohol. The study subjects consisted of 26 male workers in a steelworks factory, employed in the electrical maintenance sector, with previous exposure to a mixture of PCB (exposed subjects), and 30 male workers with no occupational exposure to PCB (controls). All subjects were given a questionnaire and peripheral venous blood samples were taken to determine serum PCB (33 congeners), total cholesterol and triglycerides, leukocytes, total lymphocytes and the T lymphocyte subpopulations (TCR α-β, TCRγ-δ, CD4+ and Treg lymphocytes). PCB, even though at a very low concentration, were significantly higher in exposed subjects than controls, and were significantly correlated with age. Monocytes% and CD4+ were significantly reduced in the exposed subjects as compared to the controls. The serum concentration of PCB positively correlated with TCR α-β, and negatively with TCRγ-δ. Treg lymphocytes showed a positive dependence on tobacco smoking, while the monocytes% and CD4+ showed a negative and positive dependence, respectively, on alcohol intake. Our results seem to show some effects of slight exposure to PCB in particular reducing the relative concentration of TCRγ-δ. This effect can favour indirectly the increase in Treg induced by smoking, the anti-inflammatory or proinflammatory/fibrogenetic/angiogenetic effect of which, exerted by produced cytokines, particularly TGF-β, deserves further clarification.

Original languageEnglish
Pages (from-to)1041-1054
Number of pages14
JournalInternational Journal of Immunopathology and Pharmacology
Volume25
Issue number4
Publication statusPublished - Oct 2012

Fingerprint

Polychlorinated Biphenyls
Smoking
Alcohols
Lymphocytes
Monocytes
Lymphocyte Subsets
Regulatory T-Lymphocytes
Occupational Exposure
Serum
Triglycerides
Leukocytes
Anti-Inflammatory Agents
Cholesterol
Maintenance
Cytokines
T-Lymphocytes

Keywords

  • Alcohol
  • Immunotoxicity
  • Polychlorinated biphenyls
  • Regulatory T cells
  • Tobacco smoke

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

Cite this

D'Errico, M. N., De Tullio, G., Di Gioacchino, M., Lovreglio, P., Basso, A., Drago, I., ... Soleo, L. (2012). Immune effects of polychlorinated biphenyls, smoking and alcohol. International Journal of Immunopathology and Pharmacology, 25(4), 1041-1054.

Immune effects of polychlorinated biphenyls, smoking and alcohol. / D'Errico, Maria Nicolà; De Tullio, G.; Di Gioacchino, M.; Lovreglio, P.; Basso, A.; Drago, I.; Serra, R.; Apostoli, P.; Vacca, A.; Soleo, L.

In: International Journal of Immunopathology and Pharmacology, Vol. 25, No. 4, 10.2012, p. 1041-1054.

Research output: Contribution to journalArticle

D'Errico, MN, De Tullio, G, Di Gioacchino, M, Lovreglio, P, Basso, A, Drago, I, Serra, R, Apostoli, P, Vacca, A & Soleo, L 2012, 'Immune effects of polychlorinated biphenyls, smoking and alcohol', International Journal of Immunopathology and Pharmacology, vol. 25, no. 4, pp. 1041-1054.
D'Errico MN, De Tullio G, Di Gioacchino M, Lovreglio P, Basso A, Drago I et al. Immune effects of polychlorinated biphenyls, smoking and alcohol. International Journal of Immunopathology and Pharmacology. 2012 Oct;25(4):1041-1054.
D'Errico, Maria Nicolà ; De Tullio, G. ; Di Gioacchino, M. ; Lovreglio, P. ; Basso, A. ; Drago, I. ; Serra, R. ; Apostoli, P. ; Vacca, A. ; Soleo, L. / Immune effects of polychlorinated biphenyls, smoking and alcohol. In: International Journal of Immunopathology and Pharmacology. 2012 ; Vol. 25, No. 4. pp. 1041-1054.
@article{da98b833e81f41069b59fa92e8beed5f,
title = "Immune effects of polychlorinated biphenyls, smoking and alcohol",
abstract = "Polychlorinated biphenyls (PCB) have been shown to exert some immune effects. Here we analysed their effects also on immune parameters not previously studied such as TCR α-β, TCR γ-δ and regulatory T cells (Treg), taking into account the specific and cumulative interference of smoking and alcohol. The study subjects consisted of 26 male workers in a steelworks factory, employed in the electrical maintenance sector, with previous exposure to a mixture of PCB (exposed subjects), and 30 male workers with no occupational exposure to PCB (controls). All subjects were given a questionnaire and peripheral venous blood samples were taken to determine serum PCB (33 congeners), total cholesterol and triglycerides, leukocytes, total lymphocytes and the T lymphocyte subpopulations (TCR α-β, TCRγ-δ, CD4+ and Treg lymphocytes). PCB, even though at a very low concentration, were significantly higher in exposed subjects than controls, and were significantly correlated with age. Monocytes{\%} and CD4+ were significantly reduced in the exposed subjects as compared to the controls. The serum concentration of PCB positively correlated with TCR α-β, and negatively with TCRγ-δ. Treg lymphocytes showed a positive dependence on tobacco smoking, while the monocytes{\%} and CD4+ showed a negative and positive dependence, respectively, on alcohol intake. Our results seem to show some effects of slight exposure to PCB in particular reducing the relative concentration of TCRγ-δ. This effect can favour indirectly the increase in Treg induced by smoking, the anti-inflammatory or proinflammatory/fibrogenetic/angiogenetic effect of which, exerted by produced cytokines, particularly TGF-β, deserves further clarification.",
keywords = "Alcohol, Immunotoxicity, Polychlorinated biphenyls, Regulatory T cells, Tobacco smoke",
author = "D'Errico, {Maria Nicol{\`a}} and {De Tullio}, G. and {Di Gioacchino}, M. and P. Lovreglio and A. Basso and I. Drago and R. Serra and P. Apostoli and A. Vacca and L. Soleo",
year = "2012",
month = "10",
language = "English",
volume = "25",
pages = "1041--1054",
journal = "International Journal of Immunopathology and Pharmacology",
issn = "0394-6320",
publisher = "Biomedical Research Press s.a.s.",
number = "4",

}

TY - JOUR

T1 - Immune effects of polychlorinated biphenyls, smoking and alcohol

AU - D'Errico, Maria Nicolà

AU - De Tullio, G.

AU - Di Gioacchino, M.

AU - Lovreglio, P.

AU - Basso, A.

AU - Drago, I.

AU - Serra, R.

AU - Apostoli, P.

AU - Vacca, A.

AU - Soleo, L.

PY - 2012/10

Y1 - 2012/10

N2 - Polychlorinated biphenyls (PCB) have been shown to exert some immune effects. Here we analysed their effects also on immune parameters not previously studied such as TCR α-β, TCR γ-δ and regulatory T cells (Treg), taking into account the specific and cumulative interference of smoking and alcohol. The study subjects consisted of 26 male workers in a steelworks factory, employed in the electrical maintenance sector, with previous exposure to a mixture of PCB (exposed subjects), and 30 male workers with no occupational exposure to PCB (controls). All subjects were given a questionnaire and peripheral venous blood samples were taken to determine serum PCB (33 congeners), total cholesterol and triglycerides, leukocytes, total lymphocytes and the T lymphocyte subpopulations (TCR α-β, TCRγ-δ, CD4+ and Treg lymphocytes). PCB, even though at a very low concentration, were significantly higher in exposed subjects than controls, and were significantly correlated with age. Monocytes% and CD4+ were significantly reduced in the exposed subjects as compared to the controls. The serum concentration of PCB positively correlated with TCR α-β, and negatively with TCRγ-δ. Treg lymphocytes showed a positive dependence on tobacco smoking, while the monocytes% and CD4+ showed a negative and positive dependence, respectively, on alcohol intake. Our results seem to show some effects of slight exposure to PCB in particular reducing the relative concentration of TCRγ-δ. This effect can favour indirectly the increase in Treg induced by smoking, the anti-inflammatory or proinflammatory/fibrogenetic/angiogenetic effect of which, exerted by produced cytokines, particularly TGF-β, deserves further clarification.

AB - Polychlorinated biphenyls (PCB) have been shown to exert some immune effects. Here we analysed their effects also on immune parameters not previously studied such as TCR α-β, TCR γ-δ and regulatory T cells (Treg), taking into account the specific and cumulative interference of smoking and alcohol. The study subjects consisted of 26 male workers in a steelworks factory, employed in the electrical maintenance sector, with previous exposure to a mixture of PCB (exposed subjects), and 30 male workers with no occupational exposure to PCB (controls). All subjects were given a questionnaire and peripheral venous blood samples were taken to determine serum PCB (33 congeners), total cholesterol and triglycerides, leukocytes, total lymphocytes and the T lymphocyte subpopulations (TCR α-β, TCRγ-δ, CD4+ and Treg lymphocytes). PCB, even though at a very low concentration, were significantly higher in exposed subjects than controls, and were significantly correlated with age. Monocytes% and CD4+ were significantly reduced in the exposed subjects as compared to the controls. The serum concentration of PCB positively correlated with TCR α-β, and negatively with TCRγ-δ. Treg lymphocytes showed a positive dependence on tobacco smoking, while the monocytes% and CD4+ showed a negative and positive dependence, respectively, on alcohol intake. Our results seem to show some effects of slight exposure to PCB in particular reducing the relative concentration of TCRγ-δ. This effect can favour indirectly the increase in Treg induced by smoking, the anti-inflammatory or proinflammatory/fibrogenetic/angiogenetic effect of which, exerted by produced cytokines, particularly TGF-β, deserves further clarification.

KW - Alcohol

KW - Immunotoxicity

KW - Polychlorinated biphenyls

KW - Regulatory T cells

KW - Tobacco smoke

UR - http://www.scopus.com/inward/record.url?scp=84872975253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872975253&partnerID=8YFLogxK

M3 - Article

C2 - 23298494

AN - SCOPUS:84872975253

VL - 25

SP - 1041

EP - 1054

JO - International Journal of Immunopathology and Pharmacology

JF - International Journal of Immunopathology and Pharmacology

SN - 0394-6320

IS - 4

ER -