TY - JOUR
T1 - Immune mechanisms in neoplasia
AU - Castelli, Chiara
AU - Dalerba, Piero
AU - Casati, Chiara
AU - Novellino, Luisa
AU - Parmiani, Giorgio
AU - De Filippo, Annamaria
PY - 2004/12
Y1 - 2004/12
N2 - Tumor can be recognized by the immune system the witnessed extraordinary advances in our understanding of tumor-host interactions. Here, we review evidence supporting the double role of the adaptive immune system in exerting both host-protecting tumor-shaping actions. We will then some of the molecular mechanisms of the adaptive immune response tumor to grow in an immonocompetent host, along with strategies that can potentially overcome the ability of the tumor to evade the immune system.
AB - Tumor can be recognized by the immune system the witnessed extraordinary advances in our understanding of tumor-host interactions. Here, we review evidence supporting the double role of the adaptive immune system in exerting both host-protecting tumor-shaping actions. We will then some of the molecular mechanisms of the adaptive immune response tumor to grow in an immonocompetent host, along with strategies that can potentially overcome the ability of the tumor to evade the immune system.
UR - http://www.scopus.com/inward/record.url?scp=23744467432&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23744467432&partnerID=8YFLogxK
U2 - 10.1016/j.ddmec.2004.11.007
DO - 10.1016/j.ddmec.2004.11.007
M3 - Article
AN - SCOPUS:23744467432
VL - 1
SP - 375
EP - 381
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
SN - 1740-6765
IS - 3
ER -