Immune mechanisms of AL amyloidosis

Research output: Contribution to journalArticle


Light chain amyloidosis (AL) is both a disorder of protein conformation a dyscrasia, with secretion of altered chains that polymerize systemitally into amyloid fibrils to organ failure. Knowledge of features of amyloid of the mechanisms determining chain organ targeting cytotoxicity is improving rapidly. Manipulation of the immune response via or active immynotherapy could open new perspectives for the therapy of complex disorder.

Original languageEnglish
Pages (from-to)365-373
Number of pages9
JournalDrug Discovery Today: Disease Mechanisms
Issue number3
Publication statusPublished - Dec 2004

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

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