Immune-mediated epilepsies

Tiziana Granata, Helen Cross, William Theodore, Giuliano Avanzini

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

A pathogenic role of immunity in epilepsies has long been suggested based on observations of the efficacy of immune-modulating treatments and, more recently, by the finding of inflammation markers including autoantibodies in individuals with a number of epileptic disorders. Clinical and experimental data suggest that both innate and adaptive immunity may be involved in epilepsy. Innate immunity represents an immediate, nonspecific host response against pathogens via activation of resident brain immune cells and inflammatory mediators. These are hypothesized to contribute to seizures and epileptogenesis. Adaptive immunity employs activation of antigen-specific B and T lymphocytes or antibodies in the context of viral infections and autoimmune disorders. In this article we critically review the evidence for pathogenic roles of adaptive immune responses in several types of epilepsy, and discuss potential mechanisms and therapeutic targets. We highlight future directions for preclinical and clinical research that are required for improved diagnosis and treatment of immune-mediated epilepsies.

Original languageEnglish
Pages (from-to)5-11
Number of pages7
JournalEpilepsia
Volume52
Issue numberSUPPL. 3
DOIs
Publication statusPublished - May 2011

Fingerprint

Epilepsy
Adaptive Immunity
Innate Immunity
Virus Diseases
Autoantibodies
Immunity
Seizures
B-Lymphocytes
Inflammation
T-Lymphocytes
Antigens
Antibodies
Brain
Research
Therapeutics

Keywords

  • Hemiconvulsion-hemiplegia
  • Immune-mediated disease
  • Infantile spasms
  • Inflammation
  • Rasmussen's encephalitis
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Granata, T., Cross, H., Theodore, W., & Avanzini, G. (2011). Immune-mediated epilepsies. Epilepsia, 52(SUPPL. 3), 5-11. https://doi.org/10.1111/j.1528-1167.2011.03029.x

Immune-mediated epilepsies. / Granata, Tiziana; Cross, Helen; Theodore, William; Avanzini, Giuliano.

In: Epilepsia, Vol. 52, No. SUPPL. 3, 05.2011, p. 5-11.

Research output: Contribution to journalArticle

Granata, T, Cross, H, Theodore, W & Avanzini, G 2011, 'Immune-mediated epilepsies', Epilepsia, vol. 52, no. SUPPL. 3, pp. 5-11. https://doi.org/10.1111/j.1528-1167.2011.03029.x
Granata T, Cross H, Theodore W, Avanzini G. Immune-mediated epilepsies. Epilepsia. 2011 May;52(SUPPL. 3):5-11. https://doi.org/10.1111/j.1528-1167.2011.03029.x
Granata, Tiziana ; Cross, Helen ; Theodore, William ; Avanzini, Giuliano. / Immune-mediated epilepsies. In: Epilepsia. 2011 ; Vol. 52, No. SUPPL. 3. pp. 5-11.
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