Immune-Mediated Inner Ear Disease

Claudio Lunardi, Antonio Puccetti

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Inner ear damage can be caused by viral infections, trauma, vascular damage, and immune mechanisms, and is responsible for sensorineural hearing loss, a syndrome characterized by rapid progression of hearing impairment that is frequently non-responsive to medical treatment. Immune-mediated inner ear disease can be of autoimmune origin either as an isolated process affecting only the ear, to be considered as an organ-specific autoimmune disease, or as part of a systemic autoimmune disorder in approximately 30% of cases. The incidence and prevalence of autoimmune inner ear disease is unknown due to the lack of reliable diagnostic tests and to the limited access to the site of autoimmune aggression. Since the rapid administration of steroids and/or other immunosuppressive agents may result in hearing preservation, a great effort is needed in order to find both clinical and immunological features able to identify these patients. Animal models of autoimmune inner ear disease may help in this effort to clarify the largely unknown pathophysiology of the disease and the response to therapy.

Original languageEnglish
Title of host publicationThe Autoimmune Diseases: Fifth Edition
PublisherElsevier Inc.
Pages805-816
Number of pages12
ISBN (Print)9780123849298
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Labyrinth Diseases
Sensorineural Hearing Loss
Inner Ear
Virus Diseases
Immunosuppressive Agents
Aggression
Hearing Loss
Routine Diagnostic Tests
Hearing
Autoimmune Diseases
Ear
Blood Vessels
Animal Models
Steroids
Incidence
Wounds and Injuries
Therapeutics

Keywords

  • Autoimmune inner ear disease
  • Cogan's syndrome
  • Inner ear antigens
  • Sensorineural hearing loss
  • Systemic autoimmune diseases

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Lunardi, C., & Puccetti, A. (2013). Immune-Mediated Inner Ear Disease. In The Autoimmune Diseases: Fifth Edition (pp. 805-816). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-384929-8.00056-3

Immune-Mediated Inner Ear Disease. / Lunardi, Claudio; Puccetti, Antonio.

The Autoimmune Diseases: Fifth Edition. Elsevier Inc., 2013. p. 805-816.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lunardi, C & Puccetti, A 2013, Immune-Mediated Inner Ear Disease. in The Autoimmune Diseases: Fifth Edition. Elsevier Inc., pp. 805-816. https://doi.org/10.1016/B978-0-12-384929-8.00056-3
Lunardi C, Puccetti A. Immune-Mediated Inner Ear Disease. In The Autoimmune Diseases: Fifth Edition. Elsevier Inc. 2013. p. 805-816 https://doi.org/10.1016/B978-0-12-384929-8.00056-3
Lunardi, Claudio ; Puccetti, Antonio. / Immune-Mediated Inner Ear Disease. The Autoimmune Diseases: Fifth Edition. Elsevier Inc., 2013. pp. 805-816
@inbook{8ea031730ba14a83a869313cb0e00491,
title = "Immune-Mediated Inner Ear Disease",
abstract = "Inner ear damage can be caused by viral infections, trauma, vascular damage, and immune mechanisms, and is responsible for sensorineural hearing loss, a syndrome characterized by rapid progression of hearing impairment that is frequently non-responsive to medical treatment. Immune-mediated inner ear disease can be of autoimmune origin either as an isolated process affecting only the ear, to be considered as an organ-specific autoimmune disease, or as part of a systemic autoimmune disorder in approximately 30{\%} of cases. The incidence and prevalence of autoimmune inner ear disease is unknown due to the lack of reliable diagnostic tests and to the limited access to the site of autoimmune aggression. Since the rapid administration of steroids and/or other immunosuppressive agents may result in hearing preservation, a great effort is needed in order to find both clinical and immunological features able to identify these patients. Animal models of autoimmune inner ear disease may help in this effort to clarify the largely unknown pathophysiology of the disease and the response to therapy.",
keywords = "Autoimmune inner ear disease, Cogan's syndrome, Inner ear antigens, Sensorineural hearing loss, Systemic autoimmune diseases",
author = "Claudio Lunardi and Antonio Puccetti",
year = "2013",
month = "12",
doi = "10.1016/B978-0-12-384929-8.00056-3",
language = "English",
isbn = "9780123849298",
pages = "805--816",
booktitle = "The Autoimmune Diseases: Fifth Edition",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Immune-Mediated Inner Ear Disease

AU - Lunardi, Claudio

AU - Puccetti, Antonio

PY - 2013/12

Y1 - 2013/12

N2 - Inner ear damage can be caused by viral infections, trauma, vascular damage, and immune mechanisms, and is responsible for sensorineural hearing loss, a syndrome characterized by rapid progression of hearing impairment that is frequently non-responsive to medical treatment. Immune-mediated inner ear disease can be of autoimmune origin either as an isolated process affecting only the ear, to be considered as an organ-specific autoimmune disease, or as part of a systemic autoimmune disorder in approximately 30% of cases. The incidence and prevalence of autoimmune inner ear disease is unknown due to the lack of reliable diagnostic tests and to the limited access to the site of autoimmune aggression. Since the rapid administration of steroids and/or other immunosuppressive agents may result in hearing preservation, a great effort is needed in order to find both clinical and immunological features able to identify these patients. Animal models of autoimmune inner ear disease may help in this effort to clarify the largely unknown pathophysiology of the disease and the response to therapy.

AB - Inner ear damage can be caused by viral infections, trauma, vascular damage, and immune mechanisms, and is responsible for sensorineural hearing loss, a syndrome characterized by rapid progression of hearing impairment that is frequently non-responsive to medical treatment. Immune-mediated inner ear disease can be of autoimmune origin either as an isolated process affecting only the ear, to be considered as an organ-specific autoimmune disease, or as part of a systemic autoimmune disorder in approximately 30% of cases. The incidence and prevalence of autoimmune inner ear disease is unknown due to the lack of reliable diagnostic tests and to the limited access to the site of autoimmune aggression. Since the rapid administration of steroids and/or other immunosuppressive agents may result in hearing preservation, a great effort is needed in order to find both clinical and immunological features able to identify these patients. Animal models of autoimmune inner ear disease may help in this effort to clarify the largely unknown pathophysiology of the disease and the response to therapy.

KW - Autoimmune inner ear disease

KW - Cogan's syndrome

KW - Inner ear antigens

KW - Sensorineural hearing loss

KW - Systemic autoimmune diseases

UR - http://www.scopus.com/inward/record.url?scp=84902644889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902644889&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-384929-8.00056-3

DO - 10.1016/B978-0-12-384929-8.00056-3

M3 - Chapter

AN - SCOPUS:84902644889

SN - 9780123849298

SP - 805

EP - 816

BT - The Autoimmune Diseases: Fifth Edition

PB - Elsevier Inc.

ER -