Immune-mediated rippling muscle disease and myasthenia gravis

Mariela Bettini; Hernan Gonorazky; Marcelo Chaves; Ernesto Fulgenzi; Alejandra Figueredo; Silvia Christiansen; Edgardo Cristiano; Enrico S. Bertini; Marcelo Rugiero

doi:10.1016/j.jneuroim.2016.08.011

Immune-mediated rippling muscle disease and myasthenia gravis

Mariela Bettini, Hernan Gonorazky, Marcelo Chaves, Ernesto Fulgenzi, Alejandra Figueredo, Silvia Christiansen, Edgardo Cristiano, Enrico S. Bertini, Marcelo Rugiero

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Cases of acquired rippling muscle disease in association with myasthenia gravis have been reported. We present three patients with iRMD (immune-mediated rippling muscle disease) and AChR-antibody positive myasthenia gravis. None of them had thymus pathology. They presented exercise-induced muscle rippling combined with generalized myasthenia gravis. One of them had muscle biopsy showing a myopathic pattern and a patchy immunostaining with caveolin antibodies. They were successfully treated steroids and azathioprine. The immune nature of this association is supported by the response to immunotherapies and the positivity of AChR-antibodies.

Original language	English
Pages (from-to)	59-61
Number of pages	3
Journal	Journal of Neuroimmunology
Volume	299
DOIs	https://doi.org/10.1016/j.jneuroim.2016.08.011
Publication status	Published - Oct 15 2016

Keywords

AchR antibodies
Autoimmune
Caveolin
Myasthenia
Rippling

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Medicine(all)
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2016.08.011

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title = "Immune-mediated rippling muscle disease and myasthenia gravis",

abstract = "Cases of acquired rippling muscle disease in association with myasthenia gravis have been reported. We present three patients with iRMD (immune-mediated rippling muscle disease) and AChR-antibody positive myasthenia gravis. None of them had thymus pathology. They presented exercise-induced muscle rippling combined with generalized myasthenia gravis. One of them had muscle biopsy showing a myopathic pattern and a patchy immunostaining with caveolin antibodies. They were successfully treated steroids and azathioprine. The immune nature of this association is supported by the response to immunotherapies and the positivity of AChR-antibodies.",

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AU - Bettini, Mariela

AU - Gonorazky, Hernan

AU - Chaves, Marcelo

AU - Fulgenzi, Ernesto

AU - Figueredo, Alejandra

AU - Christiansen, Silvia

AU - Cristiano, Edgardo

AU - Bertini, Enrico S.

AU - Rugiero, Marcelo

PY - 2016/10/15

Y1 - 2016/10/15

N2 - Cases of acquired rippling muscle disease in association with myasthenia gravis have been reported. We present three patients with iRMD (immune-mediated rippling muscle disease) and AChR-antibody positive myasthenia gravis. None of them had thymus pathology. They presented exercise-induced muscle rippling combined with generalized myasthenia gravis. One of them had muscle biopsy showing a myopathic pattern and a patchy immunostaining with caveolin antibodies. They were successfully treated steroids and azathioprine. The immune nature of this association is supported by the response to immunotherapies and the positivity of AChR-antibodies.

AB - Cases of acquired rippling muscle disease in association with myasthenia gravis have been reported. We present three patients with iRMD (immune-mediated rippling muscle disease) and AChR-antibody positive myasthenia gravis. None of them had thymus pathology. They presented exercise-induced muscle rippling combined with generalized myasthenia gravis. One of them had muscle biopsy showing a myopathic pattern and a patchy immunostaining with caveolin antibodies. They were successfully treated steroids and azathioprine. The immune nature of this association is supported by the response to immunotherapies and the positivity of AChR-antibodies.

KW - AchR antibodies

KW - Autoimmune

KW - Caveolin

KW - Myasthenia

KW - Rippling

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Immune-mediated rippling muscle disease and myasthenia gravis

Abstract

Keywords

ASJC Scopus subject areas

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