Immune-mediated rippling muscle disease and myasthenia gravis

Mariela Bettini, Hernan Gonorazky, Marcelo Chaves, Ernesto Fulgenzi, Alejandra Figueredo, Silvia Christiansen, Edgardo Cristiano, Enrico S. Bertini, Marcelo Rugiero

Research output: Contribution to journalArticlepeer-review


Cases of acquired rippling muscle disease in association with myasthenia gravis have been reported. We present three patients with iRMD (immune-mediated rippling muscle disease) and AChR-antibody positive myasthenia gravis. None of them had thymus pathology. They presented exercise-induced muscle rippling combined with generalized myasthenia gravis. One of them had muscle biopsy showing a myopathic pattern and a patchy immunostaining with caveolin antibodies. They were successfully treated steroids and azathioprine. The immune nature of this association is supported by the response to immunotherapies and the positivity of AChR-antibodies.

Original languageEnglish
Pages (from-to)59-61
Number of pages3
JournalJournal of Neuroimmunology
Publication statusPublished - Oct 15 2016


  • AchR antibodies
  • Autoimmune
  • Caveolin
  • Myasthenia
  • Rippling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Medicine(all)
  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Immune-mediated rippling muscle disease and myasthenia gravis'. Together they form a unique fingerprint.

Cite this