TY - JOUR
T1 - Immune parameters in biological monitoring of pesticide exposure
T2 - Current knowledge and perspectives
AU - Colosio, Claudio
AU - Corsini, Emanuela
AU - Barcellini, Wilma
AU - Maroni, Marco
PY - 1999/9/5
Y1 - 1999/9/5
N2 - Exposure to pesticides can cause a number of effects on the immune system, varying from a slight modulation of immune functions to the development of clinical immune diseases. The aim of this study has been reviewing published data on immune effects of pesticides in humans, with particular attention for effects observed in absence of any other change, and to the possibility of identifying a dose effect relationship. Some evidence of immunotoxic effects in man involve organophosphorus compounds, some organochlorine insecticides (OC), some carbamates, some phenoxy herbicides, dithiocarbamates, and pentachlorophenol (PCP). The alterations are usually observed in absence of any other change; in some cases, data suggest the presence of a dose effect relationship. The prognostic significance of the observed changes is still unclear. The Authors propose a tier approach to assess immune effects in humans.
AB - Exposure to pesticides can cause a number of effects on the immune system, varying from a slight modulation of immune functions to the development of clinical immune diseases. The aim of this study has been reviewing published data on immune effects of pesticides in humans, with particular attention for effects observed in absence of any other change, and to the possibility of identifying a dose effect relationship. Some evidence of immunotoxic effects in man involve organophosphorus compounds, some organochlorine insecticides (OC), some carbamates, some phenoxy herbicides, dithiocarbamates, and pentachlorophenol (PCP). The alterations are usually observed in absence of any other change; in some cases, data suggest the presence of a dose effect relationship. The prognostic significance of the observed changes is still unclear. The Authors propose a tier approach to assess immune effects in humans.
KW - Biological monitoring
KW - Carbamates
KW - Immune system
KW - Organochlorines
KW - Organophosphates
KW - Pesticides
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U2 - 10.1016/S0378-4274(99)00100-9
DO - 10.1016/S0378-4274(99)00100-9
M3 - Article
C2 - 10511273
AN - SCOPUS:0032821260
VL - 108
SP - 285
EP - 295
JO - Toxicology Letters
JF - Toxicology Letters
SN - 0378-4274
IS - 2-3
ER -