Immune parameters in biological monitoring of pesticide exposure: Current knowledge and perspectives

Claudio Colosio, Emanuela Corsini, Wilma Barcellini, Marco Maroni

Research output: Contribution to journalArticlepeer-review

Abstract

Exposure to pesticides can cause a number of effects on the immune system, varying from a slight modulation of immune functions to the development of clinical immune diseases. The aim of this study has been reviewing published data on immune effects of pesticides in humans, with particular attention for effects observed in absence of any other change, and to the possibility of identifying a dose effect relationship. Some evidence of immunotoxic effects in man involve organophosphorus compounds, some organochlorine insecticides (OC), some carbamates, some phenoxy herbicides, dithiocarbamates, and pentachlorophenol (PCP). The alterations are usually observed in absence of any other change; in some cases, data suggest the presence of a dose effect relationship. The prognostic significance of the observed changes is still unclear. The Authors propose a tier approach to assess immune effects in humans.

Original languageEnglish
Pages (from-to)285-295
Number of pages11
JournalToxicology Letters
Volume108
Issue number2-3
DOIs
Publication statusPublished - Sep 5 1999

Keywords

  • Biological monitoring
  • Carbamates
  • Immune system
  • Organochlorines
  • Organophosphates
  • Pesticides

ASJC Scopus subject areas

  • Toxicology

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