Immune pathogenesis of hepatocellular carcinoma

Yasunari Nakamoto, Luca G. Guidotti, Christian V. Kuhlen, Patricia Fowler, Francis V. Chisari

Research output: Contribution to journalArticlepeer-review


Hepatocellular carcinoma (HCC) is a common complication of chronic hepatitis B virus (HBV) infection. The pathogenetic mechanisms potentially responsible for HCC during chronic HBV infection are not well defined. This study demonstrates that chronic immune-mediated liver cell injury triggers the development of HCC in the absence of viral transactivation, insertional mutagenesis, and genotoxic chemicals. These results strongly suggest that the immune response to HBV is both necessary and sufficient to cause liver cancer during chronic HBV infection, and that all other procarcinogenic events associated with HCC are probably dependent on this process.

Original languageEnglish
Pages (from-to)341-350
Number of pages10
JournalJournal of Experimental Medicine
Issue number2
Publication statusPublished - Jul 20 1998


  • Chronic hepatitis
  • Cytotoxic T lymphocytes
  • Hepatitis B virus
  • Hepatocellular carcinoma
  • Transgenic mice

ASJC Scopus subject areas

  • Immunology


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