Immune phenotype and serum leptin in children with obesity-related liver disease

Raffaele Iorio, Angela Sepe, Antonietta Giannattasio, Francesco Cirillo, Maria Immacolata Spagnuolo, Adriana Franzese, Silvia Fontana, Daniela Aufiero, Francesco Perna, Angela Vegnente, Giuseppe Matarese

Research output: Contribution to journalArticle

Abstract

Context: Little is known about pathogenesis of obesity-related liver disease in childhood. Data on the relationship among leptin, immunological parameters, and liver disease in obese children are lacking. Objective: Thus, the objective of this study was to evaluate immune phenotype and leptin serum levels in obese children with and without obesity-related liver disease. Design: The study was performed in two groups of consecutive obese children: the first formed by children with obesity-related liver disease, diagnosed in the presence of phronic hypertransaminasemia, liver steatosis at ultrasound, and absence of known etiologies; the second composed of children with isolated obesity. In all patients serum leptin, immunoglobulins, peripheral T, B, and natural killer (NK) cells were evaluated. Results: Twenty-three children in the first group and 16 children in the second were considered eligible. Serum leptin was increased in both groups but without any significant difference. No significant correlation was found between leptin and aminotransferases, lipid serum levels, and all tested lymphocyte subpopulations. Patients with obesity-related liver disease showed significantly higher peripheral NK and B cell counts and IgA levels than children with isolated obesity. Furthermore, no correlation was found between severity of liver disease and lymphocyte surpopulations. Conclusion: In our study, leptin did not correlate with hepatic steatosis, aminotransferases, and serum lipids. Children with obesity-related liver disease showed significantly higher peripheral NK and B cells and IgA levels. Additional studies are required to define the pathogenetic role of these immunological findings.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume91
Issue number1
DOIs
Publication statusPublished - Jan 2006

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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    Iorio, R., Sepe, A., Giannattasio, A., Cirillo, F., Spagnuolo, M. I., Franzese, A., Fontana, S., Aufiero, D., Perna, F., Vegnente, A., & Matarese, G. (2006). Immune phenotype and serum leptin in children with obesity-related liver disease. Journal of Clinical Endocrinology and Metabolism, 91(1), 341-344. https://doi.org/10.1210/jc.2005-1054