To study the function of different lymphocyte populations in the Moloney strain of murine sarcoma virus (M MuSV) tumorigenesis, we gave M MuSV injections to CBA mice selectively deprived of thymus (T) lymphocytes by thymectomy, X irradiation, and syngeneic bone marrow injection. Although no tumors appeared in the control group, 80% of the deprived mice had tumors that grew progressively and ultimately killed them. In deprived mice, grafted with a syngeneic thymus (reconstituted mice) before or after an M MuSV injection, tumors regressed or did not develope. Histologically, the lymph nodes and spleens of reconstituted mice, compared to those of deprived animals, showed repopulation of the thymus dependent areas and prominent follicles in the cortex. Moreover, tumor tissue of reconstituted mice was extensively infiltrated by lymphocytes. To evaluate the number of lymphoid cells needed to prevent or regress M MuSV tumors, we injected varying amounts of lymphoid cells into deprived mice. Even low lymphocyte numbers (10 6 cells) were sufficient to exert, in some cases, protection against M MuSV tumorigenesis. This effect was not abolished by subsequent splenectomy or antilymphocyte serum treatment. Finally, deprived mice, given repeated injections of antiserum (hyperimmune) against M MuSV, had tumors which appeared only after a prolonged latency. From these results, it is concluded that T cell population integrity is important in affording total host protection against the M MuSV tumors.
|Number of pages||6|
|Journal||Journal of the National Cancer Institute|
|Publication status||Published - 1976|
ASJC Scopus subject areas
- Cancer Research