Immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis: A case report

Federico Piffer, Guido Levi, Giampietro Marchetti, Chiara Barbieri

Research output: Contribution to journalArticle

Abstract

We present the case of a 46-year-old Caucasian male, affected by ulcerative colitis, who developed tuberculous pleurisy during immunosuppressive therapy; despite proper therapy, worsening of the radiological findings was observed. The case was discussed among an online group of Italian physicians and diagnosis of immune reconstitution inflammatory syndrome (IRIS) tuberculosis was established. Therapy was continued and full recovery was obtained. IRIS is a syndrome initially described during opportunistic infections in HIV infected after being placed in anti-retroviral therapy. It reveals itself through a wide variety of manifestations, including fever, lymphadenopathies, worsening of lung infiltrates, pleural or pericardial effusion, central nervous system involvement. Few data are available regarding the best therapeutic options. IRIS is an insidious and potentially serious complication of opportunistic infections in immunocompromised patients. The always wider diffusion of immunosuppressive therapies increases the number of patients at risk, therefore physicians need to be aware of the issue.

Original languageEnglish
Article number1103
JournalMonaldi Archives for Chest Disease
Volume89
Issue number3
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

Keywords

  • Chest ultrasound
  • Infliximab
  • IRIS
  • Thoracoscopy
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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