Abstract
We present the case of a 46-year-old Caucasian male, affected by ulcerative colitis, who developed tuberculous pleurisy during immunosuppressive therapy; despite proper therapy, worsening of the radiological findings was observed. The case was discussed among an online group of Italian physicians and diagnosis of immune reconstitution inflammatory syndrome (IRIS) tuberculosis was established. Therapy was continued and full recovery was obtained. IRIS is a syndrome initially described during opportunistic infections in HIV infected after being placed in anti-retroviral therapy. It reveals itself through a wide variety of manifestations, including fever, lymphadenopathies, worsening of lung infiltrates, pleural or pericardial effusion, central nervous system involvement. Few data are available regarding the best therapeutic options. IRIS is an insidious and potentially serious complication of opportunistic infections in immunocompromised patients. The always wider diffusion of immunosuppressive therapies increases the number of patients at risk, therefore physicians need to be aware of the issue.
| Original language | English |
|---|---|
| Article number | 1103 |
| Journal | Monaldi Archives for Chest Disease |
| Volume | 89 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
| Externally published | Yes |
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Keywords
- Chest ultrasound
- Infliximab
- IRIS
- Thoracoscopy
- Tuberculosis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis : A case report. / Piffer, Federico; Levi, Guido; Marchetti, Giampietro; Barbieri, Chiara.
In: Monaldi Archives for Chest Disease, Vol. 89, No. 3, 1103, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis
T2 - A case report
AU - Piffer, Federico
AU - Levi, Guido
AU - Marchetti, Giampietro
AU - Barbieri, Chiara
PY - 2019/1/1
Y1 - 2019/1/1
N2 - We present the case of a 46-year-old Caucasian male, affected by ulcerative colitis, who developed tuberculous pleurisy during immunosuppressive therapy; despite proper therapy, worsening of the radiological findings was observed. The case was discussed among an online group of Italian physicians and diagnosis of immune reconstitution inflammatory syndrome (IRIS) tuberculosis was established. Therapy was continued and full recovery was obtained. IRIS is a syndrome initially described during opportunistic infections in HIV infected after being placed in anti-retroviral therapy. It reveals itself through a wide variety of manifestations, including fever, lymphadenopathies, worsening of lung infiltrates, pleural or pericardial effusion, central nervous system involvement. Few data are available regarding the best therapeutic options. IRIS is an insidious and potentially serious complication of opportunistic infections in immunocompromised patients. The always wider diffusion of immunosuppressive therapies increases the number of patients at risk, therefore physicians need to be aware of the issue.
AB - We present the case of a 46-year-old Caucasian male, affected by ulcerative colitis, who developed tuberculous pleurisy during immunosuppressive therapy; despite proper therapy, worsening of the radiological findings was observed. The case was discussed among an online group of Italian physicians and diagnosis of immune reconstitution inflammatory syndrome (IRIS) tuberculosis was established. Therapy was continued and full recovery was obtained. IRIS is a syndrome initially described during opportunistic infections in HIV infected after being placed in anti-retroviral therapy. It reveals itself through a wide variety of manifestations, including fever, lymphadenopathies, worsening of lung infiltrates, pleural or pericardial effusion, central nervous system involvement. Few data are available regarding the best therapeutic options. IRIS is an insidious and potentially serious complication of opportunistic infections in immunocompromised patients. The always wider diffusion of immunosuppressive therapies increases the number of patients at risk, therefore physicians need to be aware of the issue.
KW - Chest ultrasound
KW - Infliximab
KW - IRIS
KW - Thoracoscopy
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85072401255&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072401255&partnerID=8YFLogxK
U2 - 10.4081/monaldi.2019.1103
DO - 10.4081/monaldi.2019.1103
M3 - Article
AN - SCOPUS:85072401255
VL - 89
JO - Monaldi Archives for Chest Disease
JF - Monaldi Archives for Chest Disease
SN - 1122-0643
IS - 3
M1 - 1103
ER -