Immune recovery uveitis in a iatrogenically immunosuppressed patient

Elisabetta Miserocchi, G. Modorati, R. Brancato

Research output: Contribution to journalArticle

Abstract

PURPOSE. To report a case of immune recovery uveitis (IRU) in an iatrogenically immunosuppressed human immunodeficiency virus (HIV)-negative patient. METHODS. Interventional case report. One patient was diagnosed with cytomegalovirus retinitis in the left eye while receiving immunosuppressive treatment following renal transplantation. The retinitis resolved completely with systemic ganciclovir. Further reduction of immunosuppressive treatment, causing a rapid increase in CD4-T lymphocyte count, was associated in the same eye with the occurrence of IRU consisting of anterior uveitis, vitritis, and macular edema. RESULTS. Visual acuity at IRU presentation onset was 20/200 in the left eye. After 6 weeks of follow-up, the uveitis resolved with topical and periocular steroid treatment. Visual acuity restored to 20/40. CONCLUSIONS. IRU can occur in iatrogenically immunosuppressed HIV-negative patients.

Original languageEnglish
Pages (from-to)510-512
Number of pages3
JournalEuropean Journal of Ophthalmology
Volume15
Issue number4
Publication statusPublished - Jul 2005

Keywords

  • Cytomegalovirus retinitis
  • Human immunodeficiency virus
  • Immune recovery uveitis
  • Immunosuppression

ASJC Scopus subject areas

  • Ophthalmology

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