Immune regulation by invariant NKT cells in autoimmunity

Francesca Ronchi, Marika Falcone

Research output: Contribution to journalArticle

Abstract

Invariant NKT cells are important regulators of T cell immunity and autoimmunity. In this review we describe evidence that supports their regulatory role in the prevention of autoimmune disease. Moreover, we will discuss the current knowledge on iNKT cell biology, antigen recognition, acquisition of a specific cytokine profile, and mechanism of action that suggest a key role for iNKT cells as negative regulators of autoimmune diseases.

Original languageEnglish
Pages (from-to)4827-4837
Number of pages11
JournalFrontiers in Bioscience
Volume13
Issue number13
DOIs
Publication statusPublished - 2008

Keywords

  • Autoimmune disease
  • Cytokines
  • Dendritic cells
  • Immune regulation
  • Invariant natural killer T cells
  • Regulatory T cells
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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