Immune regulation by microvascular endothelial cells: Directing innate and adaptive immunity, coagulation, and inflammation

Silvio Danese, Elisabetta Dejana, Claudio Fiocchi

Research output: Contribution to journalArticle

Abstract

An effective immune response depends not only on the proper activation, regulation, and function of immune cells, but also on their distribution and retention in diverse tissue microenvironments where they encounter a number of stimuli and other cell types. These activities are mediated by endothelial cells, which form specialized microcirculatory networks used by immune cells under both physiological and pathological circumstances. Endothelial cells represent a highly heterogeneous population of cells with the ability to interact with and modulate the function of immune cells. This review is focused on the role of microvascular endothelial cells in innate and adaptive immunity, inflammation, coagulation, angiogenesis, and the therapeutic implications of targeting endothelial cells in seated autoimmune and chronic inflammatory disorders.

Original languageEnglish
Pages (from-to)6017-6022
Number of pages6
JournalJournal of Immunology
Volume178
Issue number10
Publication statusPublished - May 15 2007

ASJC Scopus subject areas

  • Immunology

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