Immune-related Adverse Events of Pembrolizumab in a Large Real-world Cohort of Patients With NSCLC With a PD-L1 Expression ≥ 50% and Their Relationship With Clinical Outcomes

Alessio Cortellini, Alex Friedlaender, Giuseppe L. Banna, Giampiero Porzio, Melissa Bersanelli, Federico Cappuzzo, Joachim G.J.V. Aerts, Raffaele Giusti, Emilio Bria, Diego Cortinovis, Francesco Grossi, Maria R. Migliorino, Domenico Galetta, Francesco Passiglia, Rossana Berardi, Francesca Mazzoni, Vincenzo Di Noia, Diego Signorelli, Alessandro Tuzi, Alain GelibterPaolo Marchetti, Marianna Macerelli, Francesca Rastelli, Rita Chiari, Danilo Rocco, Alessandro Inno, Pietro Di Marino, Giovanni Mansueto, Federica Zoratto, Matteo Santoni, Marianna Tudini, Michele Ghidini, Marco Filetti, Annamaria Catino, Pamela Pizzutilo, Luca Sala, Mario Alberto Occhipinti, Fabrizio Citarella, Russano Marco, Mariangela Torniai, Luca Cantini, Alessandro Follador, Vincenzo Sforza, Olga Nigro, Miriam G. Ferrara, Ettore D'Argento, Maria Giovanna Dal Bello, Claudia Proto, Carlo Genova, Alessandro Morabito

Research output: Contribution to journalArticle

Abstract

The role of immune-related adverse event (irAE) occurrence, as a surrogate predictor of the clinical efficacy of checkpoint inhibitors, has not yet been described in the setting of first-line, single-agent pembrolizumab for patients with metastatic non–small-cell lung-cancer with a programmed death-ligand 1 expression of ≥ 50%. A total of 1010 patients were evaluated, and after a 6-week landmark selection, 877 patients were included. We confirmed the irAE profile of first-line, single-agent pembrolizumab, in a large, real-life cohort of patients with non–small-cell lung-cancer with programmed death-ligand 1 expression of ≥ 50%. The occurrence of irAEs might be considered a surrogate of clinical activity and improved outcomes also in this setting.

Original languageEnglish
JournalClinical Lung Cancer
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • First line
  • irAEs
  • NSCLC
  • PD-L1
  • Pembrolizumab

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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    Cortellini, A., Friedlaender, A., Banna, G. L., Porzio, G., Bersanelli, M., Cappuzzo, F., Aerts, J. G. J. V., Giusti, R., Bria, E., Cortinovis, D., Grossi, F., Migliorino, M. R., Galetta, D., Passiglia, F., Berardi, R., Mazzoni, F., Di Noia, V., Signorelli, D., Tuzi, A., ... Morabito, A. (Accepted/In press). Immune-related Adverse Events of Pembrolizumab in a Large Real-world Cohort of Patients With NSCLC With a PD-L1 Expression ≥ 50% and Their Relationship With Clinical Outcomes. Clinical Lung Cancer. https://doi.org/10.1016/j.cllc.2020.06.010