Immune repopulation after HAART in previously untreated HIV-1-infected children

D. M. Gibb; A. Newberry; N. Klein; A. De Rossi; I. Grosch-Woerner; A. Babiker

Immune repopulation after HAART in previously untreated HIV-1-infected children

D. M. Gibb, A. Newberry, N. Klein, A. De Rossi, I. Grosch-Woerner, A. Babiker

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

In 25 vertically HIV-1-infected children receiving highly-active antiretroviral therapy, a 3-log₁₀, reduction in plasma HIV RNA load was maintained for 1 year and was associated with a doubling of the CD4-cell percentage. Most (75%) new CD4 cells carried the CD45RA marker of naive cells and there was only a small rise in memory cells (CD45RO). This pattern of Immune restoration differs from adults, and may be due to the presence of a functioning thymus in children.

Original language	English
Pages (from-to)	1331-1332
Number of pages	2
Journal	Lancet
Volume	355
Issue number	9212
Publication status	Published - Apr 15 2000

ASJC Scopus subject areas

Medicine(all)

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abstract = "In 25 vertically HIV-1-infected children receiving highly-active antiretroviral therapy, a 3-log10, reduction in plasma HIV RNA load was maintained for 1 year and was associated with a doubling of the CD4-cell percentage. Most (75%) new CD4 cells carried the CD45RA marker of naive cells and there was only a small rise in memory cells (CD45RO). This pattern of Immune restoration differs from adults, and may be due to the presence of a functioning thymus in children.",

author = "Gibb, {D. M.} and A. Newberry and N. Klein and {De Rossi}, A. and I. Grosch-Woerner and A. Babiker",

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AU - Gibb, D. M.

AU - Newberry, A.

AU - Klein, N.

AU - De Rossi, A.

AU - Grosch-Woerner, I.

AU - Babiker, A.

PY - 2000/4/15

Y1 - 2000/4/15

N2 - In 25 vertically HIV-1-infected children receiving highly-active antiretroviral therapy, a 3-log10, reduction in plasma HIV RNA load was maintained for 1 year and was associated with a doubling of the CD4-cell percentage. Most (75%) new CD4 cells carried the CD45RA marker of naive cells and there was only a small rise in memory cells (CD45RO). This pattern of Immune restoration differs from adults, and may be due to the presence of a functioning thymus in children.

AB - In 25 vertically HIV-1-infected children receiving highly-active antiretroviral therapy, a 3-log10, reduction in plasma HIV RNA load was maintained for 1 year and was associated with a doubling of the CD4-cell percentage. Most (75%) new CD4 cells carried the CD45RA marker of naive cells and there was only a small rise in memory cells (CD45RO). This pattern of Immune restoration differs from adults, and may be due to the presence of a functioning thymus in children.

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