Immune repopulation after HAART in previously untreated HIV-1-infected children

D. M. Gibb, A. Newberry, N. Klein, A. De Rossi, I. Grosch-Woerner, A. Babiker

Research output: Contribution to journalArticlepeer-review

Abstract

In 25 vertically HIV-1-infected children receiving highly-active antiretroviral therapy, a 3-log10, reduction in plasma HIV RNA load was maintained for 1 year and was associated with a doubling of the CD4-cell percentage. Most (75%) new CD4 cells carried the CD45RA marker of naive cells and there was only a small rise in memory cells (CD45RO). This pattern of Immune restoration differs from adults, and may be due to the presence of a functioning thymus in children.

Original languageEnglish
Pages (from-to)1331-1332
Number of pages2
JournalLancet
Volume355
Issue number9212
Publication statusPublished - Apr 15 2000

ASJC Scopus subject areas

  • Medicine(all)

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