Immune response markers in sentinel nodes may predict melanoma progression

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We recently reported that variable expression of immune-response genes distinguishes tumor positive sentinel nodes in melanoma patients with malignant progression from those with non-progressing disease. Our results depict sentinel nodes as sites in which immune functions are associated with metastatic disease and identify CD30 as a host immune-related cancer prognostic marker and potential therapeutic target.

Original languageEnglish
Article numbere28498
JournalOncoImmunology
Volume3
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Melanoma
Biomarkers
Neoplasms
Genes
cyhalothrin
Therapeutics

Keywords

  • CD30
  • Expression profiles
  • Lymph node
  • Melanoma
  • Sentinel node

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

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title = "Immune response markers in sentinel nodes may predict melanoma progression",
abstract = "We recently reported that variable expression of immune-response genes distinguishes tumor positive sentinel nodes in melanoma patients with malignant progression from those with non-progressing disease. Our results depict sentinel nodes as sites in which immune functions are associated with metastatic disease and identify CD30 as a host immune-related cancer prognostic marker and potential therapeutic target.",
keywords = "CD30, Expression profiles, Lymph node, Melanoma, Sentinel node",
author = "Monica Rodolfo and Chiara Castelli and Licia Rivoltini",
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AU - Castelli, Chiara

AU - Rivoltini, Licia

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AB - We recently reported that variable expression of immune-response genes distinguishes tumor positive sentinel nodes in melanoma patients with malignant progression from those with non-progressing disease. Our results depict sentinel nodes as sites in which immune functions are associated with metastatic disease and identify CD30 as a host immune-related cancer prognostic marker and potential therapeutic target.

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KW - Expression profiles

KW - Lymph node

KW - Melanoma

KW - Sentinel node

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