Immune response markers in sentinel nodes may predict melanoma progression

Monica Rodolfo; Chiara Castelli; Licia Rivoltini

doi:10.4161/onci.28498

Immune response markers in sentinel nodes may predict melanoma progression

Monica Rodolfo, Chiara Castelli, Licia Rivoltini

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article

Abstract

We recently reported that variable expression of immune-response genes distinguishes tumor positive sentinel nodes in melanoma patients with malignant progression from those with non-progressing disease. Our results depict sentinel nodes as sites in which immune functions are associated with metastatic disease and identify CD30 as a host immune-related cancer prognostic marker and potential therapeutic target.

Original language	English
Article number	e28498
Journal	OncoImmunology
Volume	3
Issue number	4
DOIs	https://doi.org/10.4161/onci.28498
Publication status	Published - 2014

Keywords

CD30
Expression profiles
Lymph node
Melanoma
Sentinel node

ASJC Scopus subject areas

Immunology and Allergy
Oncology
Immunology

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10.4161/onci.28498

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abstract = "We recently reported that variable expression of immune-response genes distinguishes tumor positive sentinel nodes in melanoma patients with malignant progression from those with non-progressing disease. Our results depict sentinel nodes as sites in which immune functions are associated with metastatic disease and identify CD30 as a host immune-related cancer prognostic marker and potential therapeutic target.",

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