Immune response to cytomegalovirus in patients with acquired-immunodeficiency syndrome related complex (ARC) and AIDS

M. C. Sirianni, A. Volpi, S. Soddu, R. Mancino, F. Aiuti, G. Rocchi

Research output: Contribution to journalArticle

Abstract

This study was undertaken with the aim of elucidating the mechanisms underlying the cell-mediated immunodeficiency seen in the acquired immunodeficiency syndrome (AIDS). An intrinsic functional defect in the in vitro surviving T lymphocytes from patients with AIDS has been described. This defect is reflected by profound reductions in both the cloning efficiency of these cells and in the number of precursor cells for response to lectins. Since many patients affected by AIDS present active cytomegalovirus (CMV) infections and impairment in CMV-specific cellular immunity, we examined the number of CMV-specific precursor cells in patients affected by the AIDS-related complex (ARC), who had serum antibodies to CMV and to the human-T-lvmphotropic retrovirus-type III (HTLV-III), recently termed human immunodeficiency virus (HIV). Their responses were compared to those of patients with AIDS and to those of healthy-CMV-seropositive and HTLV-III seronegative controls. We detected a significant reduction of precursors for cell-mediated immune response to CMV in AIDS, in comparison to normal controls and a reduction in ARC, even if not significant. In parallel, we assayed the response to phytohemoagglutinin, which was maintained in ARC and depressed in AIDS. Our results show a defect of specific cell-mediated immunity to CMV in ARC and AIDS patients.

Original languageEnglish
Pages (from-to)439-441
Number of pages3
JournalEuropean Journal of Epidemiology
Volume3
Issue number4
DOIs
Publication statusPublished - Dec 1987

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Cytomegalovirus
Acquired Immunodeficiency Syndrome
Retroviridae
Cellular Immunity
Cytomegalovirus Infections
Lectins
Organism Cloning
Cell Count
HIV
T-Lymphocytes
Antibodies

Keywords

  • AIDS
  • AIDS-related complex
  • Cytomegalovirus
  • Human-Tlymphotropic retrovirus type III

ASJC Scopus subject areas

  • Epidemiology

Cite this

Immune response to cytomegalovirus in patients with acquired-immunodeficiency syndrome related complex (ARC) and AIDS. / Sirianni, M. C.; Volpi, A.; Soddu, S.; Mancino, R.; Aiuti, F.; Rocchi, G.

In: European Journal of Epidemiology, Vol. 3, No. 4, 12.1987, p. 439-441.

Research output: Contribution to journalArticle

Sirianni, M. C. ; Volpi, A. ; Soddu, S. ; Mancino, R. ; Aiuti, F. ; Rocchi, G. / Immune response to cytomegalovirus in patients with acquired-immunodeficiency syndrome related complex (ARC) and AIDS. In: European Journal of Epidemiology. 1987 ; Vol. 3, No. 4. pp. 439-441.
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