Immune response to influenza A(H1N1)v in HIV-infected patients

Paola Sansonetti, Michela Sali, Massimiliano Fabbiani, Matteo Morandi, Rosa Martucci, Ali Danesh, Giovanni Delogu, Jesus F. Bermejo-Martin, Maurizio Sanguinetti, David Kelvin, Roberto Cauda, Giovanni Fadda, Salvatore Rubino

Research output: Contribution to journalArticlepeer-review


Introduction: HIV infection is considered a risk factor for severe outcomes of influenza A(H1N1)v infection. However, data on immune response against influenza A(H1N1)v virus in HIV-infected patients are lacking. Methodology: Data from seven HIV-positive and 14 HIV-negative patients infected with A(H1N1)v and from 23 HIV-positive and six HIV-negative asymptomatic controls were analyzed to evaluate the clinical picture, A(H1N1)v viral shedding, and the immune response against the virus. Results: Patients displayed mainly upper respiratory tract diseases (57.1%), while pneumonia was diagnosed only in HIV-negative patients (23.8% of subjects, of which 4.8% required intensive care unit admission). At day seven, 29% of HIV-infected patients were still positive for A(H1N1)v by RT-PCR on nasopharyngeal swabs. Interestingly, a persistence of CXCL10 secretion at high level and lower IL-6 levels was observed in HIV-positive subjects. The geometric mean haemagglutination inhibition titer (HI-GMT) and anti-influenza IgM levels were lower in HIV-positive individuals while anti-influenza IgG levels remained similar in the two groups. Conclusions: The immune impairment due to HIV infection could affect A(H1N1)v clearance and could lead to a lower antibody response and a persistent secretion of CXCL10 at high levels. However, the lower IL-6 secretion and treatment with highly active antiretroviral therapy (HAART) could result in a milder clinical picture.

Original languageEnglish
Pages (from-to)101-109
Number of pages9
JournalJournal of Infection in Developing Countries
Issue number1
Publication statusPublished - Jan 2014


  • Antibody response
  • Chemokines
  • Cytokines
  • HIV
  • Influenza A(H1N1)v 2009

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology
  • Parasitology
  • Virology


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