Abstract
The immunogenicity and reactogenicity of a recombinant hepatitis B vaccine was evaluated in 792 healthy 12 years olds. Three doses were administered (time 0,1,6 months); blood samples and self administered questionaries on reactogenicity were collected in a 9 month period. At the time of the first vaccine injection anti-HBc was detected in only three (0.37%) of the subjects. A protective antibody titer (>10mIU/ml) was present in 781 (98.6%) at 9 months (Geometric Mean Titer, GMT, 2951mIU/ml). Only mild local reactions and rare general symptoms were noted. These data confirme the safety and efficacy of this vaccination in Italian adolescents.
| Original language | English |
|---|---|
| Pages (from-to) | 131-135 |
| Number of pages | 5 |
| Journal | Journal of Preventive Medicine and Hygiene |
| Volume | 36 |
| Issue number | 3-4 |
| Publication status | Published - 1995 |
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Keywords
- Immunogenicity
- Italy
- Reactogenicity
- Vaccination
- Vital hepatitis B
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
Immune response to recombinant b vaccine in school aged children under field conditions. / Pregliasco, F.; Grilli, G.; Mensi, C.; Andreassi, A.; D'Addezio, E.; Vacca, F.; Nacciariti, L.; Zanetti, A.; Profeta, M.
In: Journal of Preventive Medicine and Hygiene, Vol. 36, No. 3-4, 1995, p. 131-135.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immune response to recombinant b vaccine in school aged children under field conditions
AU - Pregliasco, F.
AU - Grilli, G.
AU - Mensi, C.
AU - Andreassi, A.
AU - D'Addezio, E.
AU - Vacca, F.
AU - Nacciariti, L.
AU - Zanetti, A.
AU - Profeta, M.
PY - 1995
Y1 - 1995
N2 - The immunogenicity and reactogenicity of a recombinant hepatitis B vaccine was evaluated in 792 healthy 12 years olds. Three doses were administered (time 0,1,6 months); blood samples and self administered questionaries on reactogenicity were collected in a 9 month period. At the time of the first vaccine injection anti-HBc was detected in only three (0.37%) of the subjects. A protective antibody titer (>10mIU/ml) was present in 781 (98.6%) at 9 months (Geometric Mean Titer, GMT, 2951mIU/ml). Only mild local reactions and rare general symptoms were noted. These data confirme the safety and efficacy of this vaccination in Italian adolescents.
AB - The immunogenicity and reactogenicity of a recombinant hepatitis B vaccine was evaluated in 792 healthy 12 years olds. Three doses were administered (time 0,1,6 months); blood samples and self administered questionaries on reactogenicity were collected in a 9 month period. At the time of the first vaccine injection anti-HBc was detected in only three (0.37%) of the subjects. A protective antibody titer (>10mIU/ml) was present in 781 (98.6%) at 9 months (Geometric Mean Titer, GMT, 2951mIU/ml). Only mild local reactions and rare general symptoms were noted. These data confirme the safety and efficacy of this vaccination in Italian adolescents.
KW - Immunogenicity
KW - Italy
KW - Reactogenicity
KW - Vaccination
KW - Vital hepatitis B
UR - http://www.scopus.com/inward/record.url?scp=0029431006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029431006&partnerID=8YFLogxK
M3 - Article
VL - 36
SP - 131
EP - 135
JO - Journal of Preventive Medicine and Hygiene
JF - Journal of Preventive Medicine and Hygiene
SN - 1121-2233
IS - 3-4
ER -