Immune response to recombinant b vaccine in school aged children under field conditions

F. Pregliasco; G. Grilli; C. Mensi; A. Andreassi; E. D'Addezio; F. Vacca; L. Nacciariti; A. Zanetti; M. Profeta

Immune response to recombinant b vaccine in school aged children under field conditions

F. Pregliasco, G. Grilli, C. Mensi, A. Andreassi, E. D'Addezio, F. Vacca, L. Nacciariti, A. Zanetti, M. Profeta

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The immunogenicity and reactogenicity of a recombinant hepatitis B vaccine was evaluated in 792 healthy 12 years olds. Three doses were administered (time 0,1,6 months); blood samples and self administered questionaries on reactogenicity were collected in a 9 month period. At the time of the first vaccine injection anti-HBc was detected in only three (0.37%) of the subjects. A protective antibody titer (>10mIU/ml) was present in 781 (98.6%) at 9 months (Geometric Mean Titer, GMT, 2951mIU/ml). Only mild local reactions and rare general symptoms were noted. These data confirme the safety and efficacy of this vaccination in Italian adolescents.

Original language	English
Pages (from-to)	131-135
Number of pages	5
Journal	Journal of Preventive Medicine and Hygiene
Volume	36
Issue number	3-4
Publication status	Published - 1995

Keywords

Immunogenicity
Italy
Reactogenicity
Vaccination
Vital hepatitis B

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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title = "Immune response to recombinant b vaccine in school aged children under field conditions",

abstract = "The immunogenicity and reactogenicity of a recombinant hepatitis B vaccine was evaluated in 792 healthy 12 years olds. Three doses were administered (time 0,1,6 months); blood samples and self administered questionaries on reactogenicity were collected in a 9 month period. At the time of the first vaccine injection anti-HBc was detected in only three (0.37%) of the subjects. A protective antibody titer (>10mIU/ml) was present in 781 (98.6%) at 9 months (Geometric Mean Titer, GMT, 2951mIU/ml). Only mild local reactions and rare general symptoms were noted. These data confirme the safety and efficacy of this vaccination in Italian adolescents.",

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T1 - Immune response to recombinant b vaccine in school aged children under field conditions

AU - Pregliasco, F.

AU - Grilli, G.

AU - Mensi, C.

AU - Andreassi, A.

AU - D'Addezio, E.

AU - Vacca, F.

AU - Nacciariti, L.

AU - Zanetti, A.

AU - Profeta, M.

PY - 1995

Y1 - 1995

N2 - The immunogenicity and reactogenicity of a recombinant hepatitis B vaccine was evaluated in 792 healthy 12 years olds. Three doses were administered (time 0,1,6 months); blood samples and self administered questionaries on reactogenicity were collected in a 9 month period. At the time of the first vaccine injection anti-HBc was detected in only three (0.37%) of the subjects. A protective antibody titer (>10mIU/ml) was present in 781 (98.6%) at 9 months (Geometric Mean Titer, GMT, 2951mIU/ml). Only mild local reactions and rare general symptoms were noted. These data confirme the safety and efficacy of this vaccination in Italian adolescents.

AB - The immunogenicity and reactogenicity of a recombinant hepatitis B vaccine was evaluated in 792 healthy 12 years olds. Three doses were administered (time 0,1,6 months); blood samples and self administered questionaries on reactogenicity were collected in a 9 month period. At the time of the first vaccine injection anti-HBc was detected in only three (0.37%) of the subjects. A protective antibody titer (>10mIU/ml) was present in 781 (98.6%) at 9 months (Geometric Mean Titer, GMT, 2951mIU/ml). Only mild local reactions and rare general symptoms were noted. These data confirme the safety and efficacy of this vaccination in Italian adolescents.

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