Abstract
The immunogenicity and reactogenicity of a recombinant hepatitis B vaccine was evaluated in 792 healthy 12 years olds. Three doses were administered (time 0,1,6 months); blood samples and self administered questionaries on reactogenicity were collected in a 9 month period. At the time of the first vaccine injection anti-HBc was detected in only three (0.37%) of the subjects. A protective antibody titer (>10mIU/ml) was present in 781 (98.6%) at 9 months (Geometric Mean Titer, GMT, 2951mIU/ml). Only mild local reactions and rare general symptoms were noted. These data confirme the safety and efficacy of this vaccination in Italian adolescents.
| Original language | English |
|---|---|
| Pages (from-to) | 131-135 |
| Number of pages | 5 |
| Journal | Journal of Preventive Medicine and Hygiene |
| Volume | 36 |
| Issue number | 3-4 |
| Publication status | Published - 1995 |
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Keywords
- Immunogenicity
- Italy
- Reactogenicity
- Vaccination
- Vital hepatitis B
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
Pregliasco, F., Grilli, G., Mensi, C., Andreassi, A., D'Addezio, E., Vacca, F., Nacciariti, L., Zanetti, A., & Profeta, M. (1995). Immune response to recombinant b vaccine in school aged children under field conditions. Journal of Preventive Medicine and Hygiene, 36(3-4), 131-135.