Immune response to recombinant b vaccine in school aged children under field conditions

F. Pregliasco, G. Grilli, C. Mensi, A. Andreassi, E. D'Addezio, F. Vacca, L. Nacciariti, A. Zanetti, M. Profeta

Research output: Contribution to journalArticlepeer-review

Abstract

The immunogenicity and reactogenicity of a recombinant hepatitis B vaccine was evaluated in 792 healthy 12 years olds. Three doses were administered (time 0,1,6 months); blood samples and self administered questionaries on reactogenicity were collected in a 9 month period. At the time of the first vaccine injection anti-HBc was detected in only three (0.37%) of the subjects. A protective antibody titer (>10mIU/ml) was present in 781 (98.6%) at 9 months (Geometric Mean Titer, GMT, 2951mIU/ml). Only mild local reactions and rare general symptoms were noted. These data confirme the safety and efficacy of this vaccination in Italian adolescents.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalJournal of Preventive Medicine and Hygiene
Volume36
Issue number3-4
Publication statusPublished - 1995

Keywords

  • Immunogenicity
  • Italy
  • Reactogenicity
  • Vaccination
  • Vital hepatitis B

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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