Immune Response to Rotavirus and Gluten Sensitivity

Antonio Puccetti, Daniele Saverino, Roberta Opri, Oretta Gabrielli, Giovanna Zanoni, Andrea Pelosi, Piera Filomena Fiore, Francesca Moretta, Claudio Lunardi, Marzia Dolcino

Research output: Contribution to journalArticle

Abstract

Rotavirus is a double-stranded RNA virus belonging to the family of Reoviridae. The virus is transmitted by the faecal-oral route and infects intestinal cells causing gastroenteritis. Rotaviruses are the main cause of severe acute diarrhoea in children less than 5 years of age worldwide. In our previous work we have shown a link between rotavirus infection and celiac disease. Nonceliac gluten sensitivity (NCGS) is emerging as new clinical entity lacking specific diagnostic biomarkers which has been reported to occur in 6-10% of the population. Clinical manifestations include gastrointestinal and/or extraintestinal symptoms which recede with gluten withdrawal. The pathogenesis of the disease is still unknown. Aim of this work is to clarify some aspects of its pathogenesis using a gene array approach. Our results suggest that NCGS may have an autoimmune origin. This is based both on gene expression data (i.e., TH17-interferon signatures) and on the presence of TH17 cells and of serological markers of autoimmunity in NCGS. Our results also indicate a possible involvement of rotavirus infection in the pathogenesis of nonceliac gluten sensitivity similarly to what we have previously shown in celiac disease.

Original languageEnglish
Pages (from-to)9419204
JournalJournal of Immunology Research
Volume2018
DOIs
Publication statusPublished - 2018

Fingerprint

Glutens
Rotavirus
Rotavirus Infections
Celiac Disease
Reoviridae
Th17 Cells
Double-Stranded RNA
RNA Viruses
Gastroenteritis
Autoimmunity
Interferons
Diarrhea
Biomarkers
Viruses
Gene Expression
Population
Genes

Keywords

  • Adult
  • Autoantibodies/blood
  • Autoimmune Diseases/immunology
  • Autoimmunity
  • Celiac Disease/immunology
  • Child, Preschool
  • Diarrhea
  • Female
  • Gene Expression Profiling
  • Glutens/immunology
  • Humans
  • Male
  • Rotavirus/immunology
  • Rotavirus Infections/immunology
  • Th17 Cells/immunology

Cite this

Puccetti, A., Saverino, D., Opri, R., Gabrielli, O., Zanoni, G., Pelosi, A., ... Dolcino, M. (2018). Immune Response to Rotavirus and Gluten Sensitivity. Journal of Immunology Research, 2018, 9419204. https://doi.org/10.1155/2018/9419204

Immune Response to Rotavirus and Gluten Sensitivity. / Puccetti, Antonio; Saverino, Daniele; Opri, Roberta; Gabrielli, Oretta; Zanoni, Giovanna; Pelosi, Andrea; Fiore, Piera Filomena; Moretta, Francesca; Lunardi, Claudio; Dolcino, Marzia.

In: Journal of Immunology Research, Vol. 2018, 2018, p. 9419204.

Research output: Contribution to journalArticle

Puccetti, A, Saverino, D, Opri, R, Gabrielli, O, Zanoni, G, Pelosi, A, Fiore, PF, Moretta, F, Lunardi, C & Dolcino, M 2018, 'Immune Response to Rotavirus and Gluten Sensitivity', Journal of Immunology Research, vol. 2018, pp. 9419204. https://doi.org/10.1155/2018/9419204
Puccetti, Antonio ; Saverino, Daniele ; Opri, Roberta ; Gabrielli, Oretta ; Zanoni, Giovanna ; Pelosi, Andrea ; Fiore, Piera Filomena ; Moretta, Francesca ; Lunardi, Claudio ; Dolcino, Marzia. / Immune Response to Rotavirus and Gluten Sensitivity. In: Journal of Immunology Research. 2018 ; Vol. 2018. pp. 9419204.
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