Immune Response to Rotavirus and Gluten Sensitivity

Antonio Puccetti, Daniele Saverino, Roberta Opri, Oretta Gabrielli, Giovanna Zanoni, Andrea Pelosi, Piera Filomena Fiore, Francesca Moretta, Claudio Lunardi, Marzia Dolcino

Research output: Contribution to journalArticle


Rotavirus is a double-stranded RNA virus belonging to the family of Reoviridae. The virus is transmitted by the faecal-oral route and infects intestinal cells causing gastroenteritis. Rotaviruses are the main cause of severe acute diarrhoea in children less than 5 years of age worldwide. In our previous work we have shown a link between rotavirus infection and celiac disease. Nonceliac gluten sensitivity (NCGS) is emerging as new clinical entity lacking specific diagnostic biomarkers which has been reported to occur in 6-10% of the population. Clinical manifestations include gastrointestinal and/or extraintestinal symptoms which recede with gluten withdrawal. The pathogenesis of the disease is still unknown. Aim of this work is to clarify some aspects of its pathogenesis using a gene array approach. Our results suggest that NCGS may have an autoimmune origin. This is based both on gene expression data (i.e., TH17-interferon signatures) and on the presence of TH17 cells and of serological markers of autoimmunity in NCGS. Our results also indicate a possible involvement of rotavirus infection in the pathogenesis of nonceliac gluten sensitivity similarly to what we have previously shown in celiac disease.

Original languageEnglish
Pages (from-to)9419204
JournalJournal of Immunology Research
Publication statusPublished - 2018



  • Adult
  • Autoantibodies/blood
  • Autoimmune Diseases/immunology
  • Autoimmunity
  • Celiac Disease/immunology
  • Child, Preschool
  • Diarrhea
  • Female
  • Gene Expression Profiling
  • Glutens/immunology
  • Humans
  • Male
  • Rotavirus/immunology
  • Rotavirus Infections/immunology
  • Th17 Cells/immunology

Cite this

Puccetti, A., Saverino, D., Opri, R., Gabrielli, O., Zanoni, G., Pelosi, A., Fiore, P. F., Moretta, F., Lunardi, C., & Dolcino, M. (2018). Immune Response to Rotavirus and Gluten Sensitivity. Journal of Immunology Research, 2018, 9419204.