Immune responses in obesity models

Giuseppe Matarese, Antonio La Cava

Research output: Contribution to journalArticlepeer-review


Obesity is characterized by several neuroendocrine alterations of the circuits that control food intake and basal metabolism. Moreover, obesity is associated with alterations of the immune response determining a stage of 'low degree' of chronic inflammation leading to long-term health consequences such as atherosclerosis, cardiovascular disorders, diabetes, fatty liver disease, infections and airway inflammation. We review here the current status of available in vitro and in vivo models of obesity that allow us to better understand how nutritional alterations can impact the immune function. We also summarize the latest research on the intricate interactions between immune system and metabolism.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalDrug Discovery Today: Disease Models
Issue number3
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine


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