Immune responses to antigens of human endogenous retroviruses in patients with acute or stable multiple sclerosis

Mario Clerici, Maria Luisa Fusi, Domenico Caputo, Franca R. Guerini, Daria Trabattoni, Antonino Salvaggio, Carlo L. Cazzullo, Donatella Arienti, Maria Luisa Villa, Howard B. Urnovitz, Pasquale Ferrante

Research output: Contribution to journalArticle

Abstract

A possible role for human endogenous retroviruses (HERV) in the pathogenesis of MS was investigated by analyzing HERV peptides-stimulated proliferation and cytokine production in MS patients with acute (AMS) or stable (SMS) disease. HERV peptides specific-proliferation and type 1 cytokine production by peripheral blood mononuclear cells was observed in AMS but not in SMS individuals, in whom a type 2 cytokine profile dominates. HERV peptides-stimulated immune responses were modified by changes in disease expression; mediated by CD4 + T lymphocytes; and not related to HLA class II molecules. These data suggest the possibility of a pathogenic role for HERV and HERV-specific immune responses in MS.

Original languageEnglish
Pages (from-to)173-182
Number of pages10
JournalJournal of Neuroimmunology
Volume99
Issue number2
DOIs
Publication statusPublished - Oct 29 1999

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Keywords

  • Cell mediated immunity
  • Cytokines
  • Multiple sclerosis
  • Retroviruses

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Clerici, M., Fusi, M. L., Caputo, D., Guerini, F. R., Trabattoni, D., Salvaggio, A., Cazzullo, C. L., Arienti, D., Villa, M. L., Urnovitz, H. B., & Ferrante, P. (1999). Immune responses to antigens of human endogenous retroviruses in patients with acute or stable multiple sclerosis. Journal of Neuroimmunology, 99(2), 173-182. https://doi.org/10.1016/S0165-5728(99)00123-X