Immune surveillance and anti-tumor immune responses: An anatomical perspective

Valerie S. Zimmermann, Fabio Benigni, Anna Mondino

Research output: Contribution to journalArticle

Abstract

The development of adaptive immune responses against infectious agents relies on the initiation of antigen specific immune responses in secondary lymphoid organs and on the migration of effector cells at the site of infection. Similarly, the development of anti-tumor immunity depends on the recognition of tumor-derived antigens by specific lymphocytes in the context of the lymphoid tissues and on the re-localisation of the cells to the site of cell transformation. Here, we will review the preclinical studies, which have defined the spatial and temporal organisation of anti-tumor immunity, and discuss the implications of these findings in active immunotherapy.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalImmunology Letters
Volume98
Issue number1
DOIs
Publication statusPublished - Apr 15 2005

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Keywords

  • Lymphoid organs
  • T lymphocytes
  • Tumor antigen

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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