Immune surveillance of the liver by T cells

Research output: Contribution to journalReview articlepeer-review

Abstract

The liver is the target of several infectious, inflammatory, and neoplastic diseases, which affect hundreds of millions of people worldwide and cause an estimated death toll of more than 2 million people each year. Dysregulation of T cell responses has been implicated in the pathogenesis of these diseases; hence, it is critically important to understand the function and fate of T cells in the liver. Here, we provide an overview of the current knowledge on liver immune surveillance by conventional and invariant T cells and explore the complex cross-talk between immune cell subsets that determines the balance between hepatic immunity and tolerance.

Original languageEnglish
JournalScience immunology
Volume5
Issue number51
DOIs
Publication statusPublished - Sep 4 2020

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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