Abstract
Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm- aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.
Original language | English |
---|---|
Pages (from-to) | 1675-1679 |
Number of pages | 5 |
Journal | Current Pharmaceutical Design |
Volume | 19 |
Issue number | 9 |
Publication status | Published - 2013 |
Keywords
- Aging
- Cell senescence
- Centenarians
- Immunosenescence
- Inflammation
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology