Immune system, cell senescence, aging and longevity - inflamm-aging reappraised

Stefano Salvioli; Daniela Monti; Catia Lanzarini; Maria Conte; Chiara Pirazzini; Maria Giulia Bacalini; Paolo Garagnani; Cristina Giuliani; Elisa Fontanesi; Rita Ostan; Laura Bucci; Federica Sevini; Stella Lukas Yani; Annalaura Barbieri; Laura Lomartire; Vincenzo Borelli; Dario Vianello; Elena Bellavista; Morena Martucci; Elisa Cevenini; Elisa Pini; Maria Scurti; Fiammetta Biondi; Aurelia Santoro; Miriam Capri; Claudio Franceschi

Immune system, cell senescence, aging and longevity - inflamm-aging reappraised

Stefano Salvioli, Daniela Monti, Catia Lanzarini, Maria Conte, Chiara Pirazzini, Maria Giulia Bacalini, Paolo Garagnani, Cristina Giuliani, Elisa Fontanesi, Rita Ostan, Laura Bucci, Federica Sevini, Stella Lukas Yani, Annalaura Barbieri, Laura Lomartire, Vincenzo Borelli, Dario Vianello, Elena Bellavista, Morena Martucci, Elisa CeveniniElisa Pini, Maria Scurti, Fiammetta Biondi, Aurelia Santoro, Miriam Capri, Claudio Franceschi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm- aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.

Original language	English
Pages (from-to)	1675-1679
Number of pages	5
Journal	Current Pharmaceutical Design
Volume	19
Issue number	9
Publication status	Published - 2013

Keywords

Aging
Cell senescence
Centenarians
Immunosenescence
Inflammation

ASJC Scopus subject areas

Drug Discovery
Pharmacology

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Salvioli, S., Monti, D., Lanzarini, C., Conte, M., Pirazzini, C., Bacalini, M. G., Garagnani, P., Giuliani, C., Fontanesi, E., Ostan, R., Bucci, L., Sevini, F., Yani, S. L., Barbieri, A., Lomartire, L., Borelli, V., Vianello, D., Bellavista, E., Martucci, M., ... Franceschi, C. (2013). Immune system, cell senescence, aging and longevity - inflamm-aging reappraised. Current Pharmaceutical Design, 19(9), 1675-1679.

Immune system, cell senescence, aging and longevity - inflamm-aging reappraised. / Salvioli, Stefano; Monti, Daniela; Lanzarini, Catia; Conte, Maria; Pirazzini, Chiara; Bacalini, Maria Giulia; Garagnani, Paolo; Giuliani, Cristina; Fontanesi, Elisa; Ostan, Rita; Bucci, Laura; Sevini, Federica; Yani, Stella Lukas; Barbieri, Annalaura; Lomartire, Laura; Borelli, Vincenzo; Vianello, Dario; Bellavista, Elena; Martucci, Morena; Cevenini, Elisa; Pini, Elisa; Scurti, Maria; Biondi, Fiammetta; Santoro, Aurelia; Capri, Miriam; Franceschi, Claudio.

In: Current Pharmaceutical Design, Vol. 19, No. 9, 2013, p. 1675-1679.

Research output: Contribution to journal › Article › peer-review

Salvioli, S, Monti, D, Lanzarini, C, Conte, M, Pirazzini, C, Bacalini, MG, Garagnani, P, Giuliani, C, Fontanesi, E, Ostan, R, Bucci, L, Sevini, F, Yani, SL, Barbieri, A, Lomartire, L, Borelli, V, Vianello, D, Bellavista, E, Martucci, M, Cevenini, E, Pini, E, Scurti, M, Biondi, F, Santoro, A, Capri, M & Franceschi, C 2013, 'Immune system, cell senescence, aging and longevity - inflamm-aging reappraised', Current Pharmaceutical Design, vol. 19, no. 9, pp. 1675-1679.

Salvioli, Stefano ; Monti, Daniela ; Lanzarini, Catia ; Conte, Maria ; Pirazzini, Chiara ; Bacalini, Maria Giulia ; Garagnani, Paolo ; Giuliani, Cristina ; Fontanesi, Elisa ; Ostan, Rita ; Bucci, Laura ; Sevini, Federica ; Yani, Stella Lukas ; Barbieri, Annalaura ; Lomartire, Laura ; Borelli, Vincenzo ; Vianello, Dario ; Bellavista, Elena ; Martucci, Morena ; Cevenini, Elisa ; Pini, Elisa ; Scurti, Maria ; Biondi, Fiammetta ; Santoro, Aurelia ; Capri, Miriam ; Franceschi, Claudio. / Immune system, cell senescence, aging and longevity - inflamm-aging reappraised. In: Current Pharmaceutical Design. 2013 ; Vol. 19, No. 9. pp. 1675-1679.

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Immune system, cell senescence, aging and longevity - inflamm-aging reappraised

Abstract

Keywords

ASJC Scopus subject areas

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