Immune system, cell senescence, aging and longevity - inflamm-aging reappraised

Stefano Salvioli; Daniela Monti; Catia Lanzarini; Maria Conte; Chiara Pirazzini; Maria Giulia Bacalini; Paolo Garagnani; Cristina Giuliani; Elisa Fontanesi; Rita Ostan; Laura Bucci; Federica Sevini; Stella Lukas Yani; Annalaura Barbieri; Laura Lomartire; Vincenzo Borelli; Dario Vianello; Elena Bellavista; Morena Martucci; Elisa Cevenini; Elisa Pini; Maria Scurti; Fiammetta Biondi; Aurelia Santoro; Miriam Capri; Claudio Franceschi

Immune system, cell senescence, aging and longevity - inflamm-aging reappraised

Stefano Salvioli, Daniela Monti, Catia Lanzarini, Maria Conte, Chiara Pirazzini, Maria Giulia Bacalini, Paolo Garagnani, Cristina Giuliani, Elisa Fontanesi, Rita Ostan, Laura Bucci, Federica Sevini, Stella Lukas Yani, Annalaura Barbieri, Laura Lomartire, Vincenzo Borelli, Dario Vianello, Elena Bellavista, Morena Martucci, Elisa CeveniniElisa Pini, Maria Scurti, Fiammetta Biondi, Aurelia Santoro, Miriam Capri, Claudio Franceschi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm- aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.

Original language	English
Pages (from-to)	1675-1679
Number of pages	5
Journal	Current Pharmaceutical Design
Volume	19
Issue number	9
Publication status	Published - 2013

Keywords

Aging
Cell senescence
Centenarians
Immunosenescence
Inflammation

ASJC Scopus subject areas

Drug Discovery
Pharmacology

Cite this

Salvioli, S., Monti, D., Lanzarini, C., Conte, M., Pirazzini, C., Bacalini, M. G., Garagnani, P., Giuliani, C., Fontanesi, E., Ostan, R., Bucci, L., Sevini, F., Yani, S. L., Barbieri, A., Lomartire, L., Borelli, V., Vianello, D., Bellavista, E., Martucci, M., ... Franceschi, C. (2013). Immune system, cell senescence, aging and longevity - inflamm-aging reappraised. Current Pharmaceutical Design, 19(9), 1675-1679.

Immune system, cell senescence, aging and longevity - inflamm-aging reappraised. / Salvioli, Stefano; Monti, Daniela; Lanzarini, Catia; Conte, Maria; Pirazzini, Chiara; Bacalini, Maria Giulia; Garagnani, Paolo; Giuliani, Cristina; Fontanesi, Elisa; Ostan, Rita; Bucci, Laura; Sevini, Federica; Yani, Stella Lukas; Barbieri, Annalaura; Lomartire, Laura; Borelli, Vincenzo; Vianello, Dario; Bellavista, Elena; Martucci, Morena; Cevenini, Elisa; Pini, Elisa; Scurti, Maria; Biondi, Fiammetta; Santoro, Aurelia; Capri, Miriam; Franceschi, Claudio.

In: Current Pharmaceutical Design, Vol. 19, No. 9, 2013, p. 1675-1679.

Research output: Contribution to journal › Article › peer-review

Salvioli, S, Monti, D, Lanzarini, C, Conte, M, Pirazzini, C, Bacalini, MG, Garagnani, P, Giuliani, C, Fontanesi, E, Ostan, R, Bucci, L, Sevini, F, Yani, SL, Barbieri, A, Lomartire, L, Borelli, V, Vianello, D, Bellavista, E, Martucci, M, Cevenini, E, Pini, E, Scurti, M, Biondi, F, Santoro, A, Capri, M & Franceschi, C 2013, 'Immune system, cell senescence, aging and longevity - inflamm-aging reappraised', Current Pharmaceutical Design, vol. 19, no. 9, pp. 1675-1679.

Salvioli, Stefano ; Monti, Daniela ; Lanzarini, Catia ; Conte, Maria ; Pirazzini, Chiara ; Bacalini, Maria Giulia ; Garagnani, Paolo ; Giuliani, Cristina ; Fontanesi, Elisa ; Ostan, Rita ; Bucci, Laura ; Sevini, Federica ; Yani, Stella Lukas ; Barbieri, Annalaura ; Lomartire, Laura ; Borelli, Vincenzo ; Vianello, Dario ; Bellavista, Elena ; Martucci, Morena ; Cevenini, Elisa ; Pini, Elisa ; Scurti, Maria ; Biondi, Fiammetta ; Santoro, Aurelia ; Capri, Miriam ; Franceschi, Claudio. / Immune system, cell senescence, aging and longevity - inflamm-aging reappraised. In: Current Pharmaceutical Design. 2013 ; Vol. 19, No. 9. pp. 1675-1679.

@article{6dcdb77e677544788672cf16efbc7e44,

title = "Immune system, cell senescence, aging and longevity - inflamm-aging reappraised",

abstract = "Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm- aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.",

keywords = "Aging, Cell senescence, Centenarians, Immunosenescence, Inflammation",

author = "Stefano Salvioli and Daniela Monti and Catia Lanzarini and Maria Conte and Chiara Pirazzini and Bacalini, {Maria Giulia} and Paolo Garagnani and Cristina Giuliani and Elisa Fontanesi and Rita Ostan and Laura Bucci and Federica Sevini and Yani, {Stella Lukas} and Annalaura Barbieri and Laura Lomartire and Vincenzo Borelli and Dario Vianello and Elena Bellavista and Morena Martucci and Elisa Cevenini and Elisa Pini and Maria Scurti and Fiammetta Biondi and Aurelia Santoro and Miriam Capri and Claudio Franceschi",

year = "2013",

language = "English",

volume = "19",

pages = "1675--1679",

journal = "Current Pharmaceutical Design",

issn = "1381-6128",

publisher = "Bentham Science Publishers B.V.",

number = "9",

}

TY - JOUR

T1 - Immune system, cell senescence, aging and longevity - inflamm-aging reappraised

AU - Salvioli, Stefano

AU - Monti, Daniela

AU - Lanzarini, Catia

AU - Conte, Maria

AU - Pirazzini, Chiara

AU - Bacalini, Maria Giulia

AU - Garagnani, Paolo

AU - Giuliani, Cristina

AU - Fontanesi, Elisa

AU - Ostan, Rita

AU - Bucci, Laura

AU - Sevini, Federica

AU - Yani, Stella Lukas

AU - Barbieri, Annalaura

AU - Lomartire, Laura

AU - Borelli, Vincenzo

AU - Vianello, Dario

AU - Bellavista, Elena

AU - Martucci, Morena

AU - Cevenini, Elisa

AU - Pini, Elisa

AU - Scurti, Maria

AU - Biondi, Fiammetta

AU - Santoro, Aurelia

AU - Capri, Miriam

AU - Franceschi, Claudio

PY - 2013

Y1 - 2013

N2 - Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm- aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.

AB - Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm- aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.

KW - Aging

KW - Cell senescence

KW - Centenarians

KW - Immunosenescence

KW - Inflammation

UR - http://www.scopus.com/inward/record.url?scp=84876721938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876721938&partnerID=8YFLogxK

M3 - Article

C2 - 23589904

AN - SCOPUS:84876721938

VL - 19

SP - 1675

EP - 1679

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

SN - 1381-6128

IS - 9

ER -

Immune system, cell senescence, aging and longevity - inflamm-aging reappraised

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this