Immune transcriptome alterations in the temporal cortex of subjects with autism

Krassimira Garbett, Philip J. Ebert, Amanda Mitchell, Carla Lintas, Barbara Manzi, Károly Mirnics, Antonio M. Persico

Research output: Contribution to journalArticlepeer-review

Abstract

Autism is a severe disorder that involves both genetic and environmental factors. Expression profiling of the superior temporal gyrus of six autistic subjects and matched controls revealed increased transcript levels of many immune system-related genes. We also noticed changes in transcripts related to cell communication, differentiation, cell cycle regulation and chaperone systems. Critical expression changes were confirmed by qPCR (BCL6, CHI3L1, CYR61, IFI16, IFITM3, MAP2K3, PTDSR, RFX4, SPP1, RELN, NOTCH2, RIT1, SFN, GADD45B, HSPA6, HSPB8 and SERPINH1). Overall, these expression patterns appear to be more associated with the late recovery phase of autoimmune brain disorders, than with the innate immune response characteristic of neurodegenerative diseases. Moreover, a variance-based analysis revealed much greater transcript variability in brains from autistic subjects compared to the control group, suggesting that these genes may represent autism susceptibility genes and should be assessed in follow-up genetic studies.

Original languageEnglish
Pages (from-to)303-311
Number of pages9
JournalNeurobiology of Disease
Volume30
Issue number3
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Autism
  • DNA microarray
  • Gene expression
  • Post mortem
  • qPCR
  • Temporal cortex
  • Transcriptome

ASJC Scopus subject areas

  • Neurology

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