Immunity assessment in the early stages of amyotrophic lateral sclerosis: A study of virus antibodies and lymphocyte subsets

L. Provinciali, M. A. Laurenzi, L. Vesprini, A. R. Giovagnoli, C. Bartocci, M. Montroni, P. Bagnarelli, M. Clementi, P. E. Varaldo

Research output: Contribution to journalArticle

Abstract

Serum and CSF from 32 patients with idiopathic ALS, 30 age-matched controls and 30 MS patients were investigted regarding immunoglobulin concentration and virus-specific antibodies, the lymphocytes in the peripheral blood and lymphocyte subsets were also investigated. ALS patients' results were compared with findings in MS and controls. The ALS patients had significantly higher IgG concentration in serum than the controls, marked lymphopenia, reduction of CD2, CD8 and Leu 7 positive cells and increase of the CD4/CD8 ratio and of SIg-positive lymphocytes. Compared with the MS patients, the ALS patients showed similarity in T-subset distribution with a lower standard deviation. No HTLV-I and HIV antibodies were found in any group and no significant differences in antibody distribution to Toxoplasma G, herpes simples, cytomegalovirus, measles and mumps viruses were evident. All ALS patients were investigated at an early disease stage, therefore, our findings seem to support the conclusion that the immune alterations are related to the mechanisms of the disease and not to complications of its evolution.

Original languageEnglish
Pages (from-to)449-454
Number of pages6
JournalActa Neurologica Scandinavica
Volume78
Issue number6
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Provinciali, L., Laurenzi, M. A., Vesprini, L., Giovagnoli, A. R., Bartocci, C., Montroni, M., Bagnarelli, P., Clementi, M., & Varaldo, P. E. (1988). Immunity assessment in the early stages of amyotrophic lateral sclerosis: A study of virus antibodies and lymphocyte subsets. Acta Neurologica Scandinavica, 78(6), 449-454.