TY - JOUR
T1 - Immunization of Macaca fascicularis with inactivated SIV preparations
T2 - challenge with human- or monkey-derived SIV and the effects of a longer immunization schedule.
AU - Titti, F.
AU - Koanga Mogtomo, M. L.
AU - Borsetti, A.
AU - Geraci, A.
AU - Sernicola, L.
AU - Panzini, G.
AU - Turillazzi, G. P.
AU - Baroncelli, S.
AU - Giovannetti, A.
AU - Zamarchi, R.
PY - 1993/2
Y1 - 1993/2
N2 - In cynomolgus monkeys, we compared two human-derived SIVmac251 whole virus vaccines, a long vs short immunization schedule, and two different challenge viruses. Both vaccines induced protection after challenge with human-derived SIVmac251/32H. There was no difference between the two schedules of immunization. Seven monkeys, five of which were protected following the first challenge, were reboosted and rechallenged with monkey-derived SIVmac251, but no protection was observed. The titers of anti-human cell or -SIV neutralizing antibodies were not related to protection.
AB - In cynomolgus monkeys, we compared two human-derived SIVmac251 whole virus vaccines, a long vs short immunization schedule, and two different challenge viruses. Both vaccines induced protection after challenge with human-derived SIVmac251/32H. There was no difference between the two schedules of immunization. Seven monkeys, five of which were protected following the first challenge, were reboosted and rechallenged with monkey-derived SIVmac251, but no protection was observed. The titers of anti-human cell or -SIV neutralizing antibodies were not related to protection.
UR - http://www.scopus.com/inward/record.url?scp=0027551395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027551395&partnerID=8YFLogxK
M3 - Article
C2 - 8411103
AN - SCOPUS:0027551395
VL - 22
SP - 110
EP - 118
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 2-3
ER -