Immunization of Macaca fascicularis with inactivated SIV preparations: challenge with human- or monkey-derived SIV and the effects of a longer immunization schedule.

F. Titti; M. L. Koanga Mogtomo; A. Borsetti; A. Geraci; L. Sernicola; G. Panzini; G. P. Turillazzi; S. Baroncelli; A. Giovannetti; R. Zamarchi

Immunization of Macaca fascicularis with inactivated SIV preparations: challenge with human- or monkey-derived SIV and the effects of a longer immunization schedule.

F. Titti, M. L. Koanga Mogtomo, A. Borsetti, A. Geraci, L. Sernicola, G. Panzini, G. P. Turillazzi, S. Baroncelli, A. Giovannetti, R. Zamarchi

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

In cynomolgus monkeys, we compared two human-derived SIVmac251 whole virus vaccines, a long vs short immunization schedule, and two different challenge viruses. Both vaccines induced protection after challenge with human-derived SIVmac251/32H. There was no difference between the two schedules of immunization. Seven monkeys, five of which were protected following the first challenge, were reboosted and rechallenged with monkey-derived SIVmac251, but no protection was observed. The titers of anti-human cell or -SIV neutralizing antibodies were not related to protection.

Original language	English
Pages (from-to)	110-118
Number of pages	9
Journal	Journal of Medical Primatology
Volume	22
Issue number	2-3
Publication status	Published - Feb 1993

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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Titti, F., Koanga Mogtomo, M. L., Borsetti, A., Geraci, A., Sernicola, L., Panzini, G., Turillazzi, G. P., Baroncelli, S., Giovannetti, A., & Zamarchi, R. (1993). Immunization of Macaca fascicularis with inactivated SIV preparations: challenge with human- or monkey-derived SIV and the effects of a longer immunization schedule. Journal of Medical Primatology, 22(2-3), 110-118.

Immunization of Macaca fascicularis with inactivated SIV preparations : challenge with human- or monkey-derived SIV and the effects of a longer immunization schedule. / Titti, F.; Koanga Mogtomo, M. L.; Borsetti, A.; Geraci, A.; Sernicola, L.; Panzini, G.; Turillazzi, G. P.; Baroncelli, S.; Giovannetti, A.; Zamarchi, R.

In: Journal of Medical Primatology, Vol. 22, No. 2-3, 02.1993, p. 110-118.

Research output: Contribution to journal › Article › peer-review

Titti, F, Koanga Mogtomo, ML, Borsetti, A, Geraci, A, Sernicola, L, Panzini, G, Turillazzi, GP, Baroncelli, S, Giovannetti, A & Zamarchi, R 1993, 'Immunization of Macaca fascicularis with inactivated SIV preparations: challenge with human- or monkey-derived SIV and the effects of a longer immunization schedule.', Journal of Medical Primatology, vol. 22, no. 2-3, pp. 110-118.

Titti, F. ; Koanga Mogtomo, M. L. ; Borsetti, A. ; Geraci, A. ; Sernicola, L. ; Panzini, G. ; Turillazzi, G. P. ; Baroncelli, S. ; Giovannetti, A. ; Zamarchi, R. / Immunization of Macaca fascicularis with inactivated SIV preparations : challenge with human- or monkey-derived SIV and the effects of a longer immunization schedule. In: Journal of Medical Primatology. 1993 ; Vol. 22, No. 2-3. pp. 110-118.

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