Immunization of Macaca fascicularis with inactivated SIV preparations: challenge with human- or monkey-derived SIV and the effects of a longer immunization schedule.

F. Titti, M. L. Koanga Mogtomo, A. Borsetti, A. Geraci, L. Sernicola, G. Panzini, G. P. Turillazzi, S. Baroncelli, A. Giovannetti, R. Zamarchi

Research output: Contribution to journalArticlepeer-review

Abstract

In cynomolgus monkeys, we compared two human-derived SIVmac251 whole virus vaccines, a long vs short immunization schedule, and two different challenge viruses. Both vaccines induced protection after challenge with human-derived SIVmac251/32H. There was no difference between the two schedules of immunization. Seven monkeys, five of which were protected following the first challenge, were reboosted and rechallenged with monkey-derived SIVmac251, but no protection was observed. The titers of anti-human cell or -SIV neutralizing antibodies were not related to protection.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalJournal of Medical Primatology
Volume22
Issue number2-3
Publication statusPublished - Feb 1993

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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