Abstract
In cynomolgus monkeys, we compared two human-derived SIVmac251 whole virus vaccines, a long vs short immunization schedule, and two different challenge viruses. Both vaccines induced protection after challenge with human-derived SIVmac251/32H. There was no difference between the two schedules of immunization. Seven monkeys, five of which were protected following the first challenge, were reboosted and rechallenged with monkey-derived SIVmac251, but no protection was observed. The titers of anti-human cell or -SIV neutralizing antibodies were not related to protection.
| Original language | English |
|---|---|
| Pages (from-to) | 110-118 |
| Number of pages | 9 |
| Journal | Journal of Medical Primatology |
| Volume | 22 |
| Issue number | 2-3 |
| Publication status | Published - Feb 1993 |
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ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Titti, F., Koanga Mogtomo, M. L., Borsetti, A., Geraci, A., Sernicola, L., Panzini, G., Turillazzi, G. P., Baroncelli, S., Giovannetti, A., & Zamarchi, R. (1993). Immunization of Macaca fascicularis with inactivated SIV preparations: challenge with human- or monkey-derived SIV and the effects of a longer immunization schedule. Journal of Medical Primatology, 22(2-3), 110-118.