Immuno-Pharmacological Targeting of Virus-Containing Compartments in HIV-1-Infected Macrophages

Francesca Graziano, Elisa Vicenzi, Guido Poli

Research output: Contribution to journalReview article

Abstract

In addition to CD4 T lymphocytes, HIV-1 infects tissue macrophages that can actively accumulate infectious virions in vacuolar subcellular structures mostly connected to the plasma membrane and recently termed virus-containing compartments (VCCs). The VCC-associated HIV-1 reservoir of infected macrophages can be either increased or depleted by immunologic and pharmacologic agents, at least in vitro, thus suggesting that these factors (or related molecules) could be effective in curtailing the macrophage-associated HIV-1 reservoir in infected individuals receiving combination antiretroviral therapy (cART). Here we review evidence on the pathogenic role of tissue macrophages as long-term viral reservoirs in vivo and upon in vitro infection with a particular emphasis on the immuno-pharmacological modulation of VCCs.

Original languageEnglish
Pages (from-to)558-567
Number of pages10
JournalTrends in Microbiology
Volume24
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • ATP
  • HIV (human immunodeficiency virus)
  • macrophages
  • microvesicles
  • P2X
  • VCC (virus-containing compartment)

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology

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